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Researchers find 150 possible inhibitors to fight Nipah virus
A group of scientists from India have used 3D imaging of the Nipah virus to discover potential inhibitors for the disease.
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Imaging
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Advanced imaging technique could be used to image living cells faster
Researchers have used ghost imaging to enhance the imaging speed of nanoscopy, which could make it possible to capture processes in living cells at speeds not previously possible.
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Appearance of proteins used to predict function with machine learning
Researchers have used a machine-learning algorithm to study protein appearance and discover common features that influence function, which could be used to design artificial cells.
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Structure of key pneumonia virus enzyme uncovered
Scientists have used cryo-electron microscopy to clarify the structure of one of the key components of RSV and HMPV, which could lead to new therapies for the viruses.
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Drug Target Review – Issue 4 2019
This issue includes a discussion on the future of high-throughput screening through collaboration, an analysis of mass spectrometry as a structural biology tool and an exploration of the challenges of hit-to-lead when researching tropical diseases. Also in the issue are articles on immuno-oncology and assays.
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Cancer immunotherapies may be improved with early immune response
A new mechanism has been reported for detecting foreign material during early immune responses which may help detect elusive cancers.
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Researchers use imaging to reveal early stages of colon cancer
A study has demonstrated how mutations in early colon cancer prevail and grow into malignancies, using fluorescent imaging.
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Application note: Detect endotoxin with the PyroGene Recombinant Factor C Assay
Get increased sensitivity for the detection of endotoxin in a fluorescence assay.
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Faster 3D imaging possible with novel microscopy approach
A novel imaging approach has been developed which could lead to new discoveries in biology and medicine.
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ELRIG Drug Discovery 2019: looking back to the future
On 5-6 November, ACC Liverpool hosted the ELRIG Drug Discovery event, which allowed R&D professionals to come together and discuss the latest industry developments.
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Application note: A Simoa ™ Pharmacokinetic Bridging Assay
Pharmacokinetics (PK) refers to the movement of a drug through the body. The distribution, absorption, metabolism, and excretion of a drug are all important pharmacokinetic factors to be considered in the development of therapeutics.
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T-box and tRNA complex structure revealed by study
A team of researchers has uncovered the structure of a T-box regulatory mechanism in bacteria, which could aid in the development of novel antibiotics.
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Protein imaging equipment enables enzymes to be observed in real-time
The imaging equipment, European XFEL, is said to mark a new age of protein movie-making and enables enzymes involved in disease to be observed in real-time.
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Application note: Automated Extraction of High Molecular Weight DNA
SmartExtraction significantly simplifies the entire automated workflow of DNA extraction.
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Application note: Multiplex Fluorescent Western Blot Detection
Challenge: One touch imaging of multiple proteins on the same blot with NIR fluorescent tags. Solution? Automated imaging with the UVP ChemStudio.
