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Article: Linking genomics with proteomics to accelerate the search for drug targets
Several recent studies highlight the promise of combining genomics and proteomics to uncover new, robust drug targets.
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Omics
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Scientists develop synthetic cell that grows and divides uniformly
Researchers have created a single-celled synthetic organism able to grow and divide that could be used to produce drugs and detect disease.
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Hydrogel used to revert cancer cells back to cancer stem cells
A new hydrogel has been shown to convert cancer cells to cancer stem cells within 24 hours, in six different human cancer cell line types.
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Novel technique provides detailed map of lung pathology in COVID-19
Researchers have used imaging mass cytometry to analyse the cellular landscape of diseased lung tissue in severe COVID-19, revealing insights into the disease.
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Antibody could be used in tooth regeneration therapy, study shows
A mAb could be used in tooth regeneration therapy, after a single administration generated new teeth in mice and ferrets.
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Platelet-based therapeutic formulation targets tumours in mouse models
A new delivery vector using platelets has shown success in pre-clinical trials at delivering photothermal particles and immunostimulators to tumours.
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Aptamer inhibits SARS-CoV-2 with novel mechanism of action, study shows
An aptamer that can bind a different part of SARS-CoV-2 than known inhibitors could enhance treatments against coronavirus mutations.
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Antibodies and remdesivir used to treat Marburg virus in rhesus macaques
The combination of mAbs and remdesivir induced an 80 percent protection rate against Marburg virus in rhesus macaques, according to a new study.
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Novel label-free assay developed to profile immune response to infection
Researchers have created an immune assay that can profile host immune responses to infection and is faster than current methods.
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Nanoparticle vaccine shown to block range of flu strains in pre-clinical study
A new vaccine formulated with nanoparticles protected animal models from a variety of seasonal and pandemic influenza strains.
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Organ-on-a-chip model developed to aid sickle cell disease treatment
Researchers have developed a novel organ-on-a-chip model of sickle cell disease to improve personalised medicine.
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Drug Target Review – Issue 1 2021
In this issue, find articles discussing how high-throughput experimentation can enhance automated molecular discovery, why bNAbs present a promising COVID-19 treatment and how a novel rhinovirus vaccine was developed. Also included are features on immuno-oncology, cell line development and assays.
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First 3D images of Survival Motor Neuron complex visualised
Researchers have imaged the entire Survival Motor Neuron complex using X-ray diffraction analysis, among other techniques.
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Whitepaper: Simple Western™ produces publication-ready results
Simple Western™ is an automated capillary immunoassay that produces publication-ready data to meet the highest standards of data integrity and rigor.
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Unpredicted binding found between SARS-CoV-2 and hepatitis C drug, telaprevir
Insights into the interaction between telaprevir and the SARS-CoV-2 main protease could aid in future COVID-19 drug design, say scientists.
