Screening

eBook: Simple as a Selfie: One-Button Scientific Imaging

13 November 2019 | By Analytik Jena

Proper signal visualization, detection, and quantification are paramount to the acquisition of accurate and reproducible data...

Application note: In Vivo Imaging with GFP

12 November 2019 | By Analytik Jena

Challenge: Non-invasive imaging of a patient-derived orthotropic mouse model of pancreatic cancer expressing GFP. The solution? In vivo imaging.

eBook – Getting the Inside Story: In Vivo Imaging

12 November 2019 | By Analytik Jena

In vivo imaging has been an indispensable and powerful tool in biomedical research, enabling a number of significant breakthrough discoveries.

Analytik Jena

Liver-Chip used to study toxicity of drug candidates

7 November 2019 | By Victoria Rees (Drug Target Review)

Researchers have made a ‘Liver-Chip’ which is able to demonstrate the toxic effects of drug candidates and compounds in human patients.

Study aims to boost antitumoral activity of compound in Amazon plant

1 November 2019 | By Rachael Harper (Drug Target Review)

Scientists seek to design therapeutically more potent chemicals from alkaloids produced by the plant, Uncaria guianensis, which could aid in combatting tumours.

Application note: Reliable Single Cell Cloning with Advanced Microfluidic Dispensing

24 October 2019 | By Sphere Fluidics Ltd.

Find out how to accelerate and improve selective single cell cloning with advanced microfluidic dispensing.

Machine-learning algorithm developed to aid in epigenetic drug discovery

23 October 2019 | By Rachael Harper (Drug Target Review)

A machine-learning algorithm has been created that automates high-throughput screens of epigenetic medicines.

New horizons in small molecule solubility screening

22 October 2019 | By Halo Labs

Aqueous solubility of small molecule compounds is an essential parameter during the hit-to-lead stage of drug discovery as well as lead optimization and formulation. Low solubility can result in misleading ADMET/DMPK analyses if some fraction of a compound precipitates. Watch on-demand to find out more!

CRISPR RNA-cutting enzyme programmed to kill viruses in human cells

14 October 2019 | By Rachael Harper (Drug Target Review)

Researchers have developed CRISPR-Cas13 enzyme-based technology that can be programmed to both detect and destroy RNA-based viruses in human cells.

3D tissue models of brain tumours created in brain-mimicking environment

11 October 2019 | By Rachael Harper (Drug Target Review)

A new platform has the potential to better understand what dictates the invasive behaviour of brain tumours.

New compound keeps cells alive and functioning in a healthy state

7 October 2019 | By Rachael Harper (Drug Target Review)

A world-first compound that can keep cells alive and functioning in a healthy state could be revolutionary for medical emergencies.

The challenges of hit-to-lead in drug discovery

7 October 2019 | By Victoria Rees (Drug Target Review)

A study that identified 12 novel compounds that may prove valuable against new drug targets for leishmaniasis and Chagas disease was not without complication. Here, we discuss the findings but also the challenges the researchers reported in their hit-to-lead study.

Application note: Explore cardiac function by measuring calcium oscillation or contraction patterns

4 October 2019 | By Molecular Devices

Understanding the impact of drugs on the cardiac system early in the development process is critical to improving the safety of drugs getting to market.

In vitro toxicology and toxicity testing market to exhibit CAGR of 9.3 percent

2 October 2019 | By Victoria Rees (Drug Target Review)

The worldwide market for in vitro toxicology and toxicity testing is predicted to be worth $12.7 billion by the end of the forecast period.