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Scientists have found that when two specific genes are deleted in benign tumour tissue in the intestines, it more rapidly develops into a tumour that is more likely to become cancerous.
Drug Target Review lists its 10 most popular news stories from 2019, summarising the drug targets that you wanted to read about.
Researchers have developed a 'scar in a dish' model derived from human stem cells which mimics the progressive scarring that occurs in human organs and has lead to a drug candidate being identified to stop the progression of fibrosis.
Immune cell therapies, stem cell therapies, and regenerative medicine, often grouped into the category of advanced therapy medicinal products (ATMPs), offer some of the most revolutionary and exciting new approaches for treating human disease.
A study has demonstrated that activating bone periosteal stem cells leads to increased bone healing in mice, presenting a potential therapeutic strategy.
This issue includes a discussion on the future of high-throughput screening through collaboration, an analysis of mass spectrometry as a structural biology tool and an exploration of the challenges of hit-to-lead when researching tropical diseases. Also in the issue are articles on immuno-oncology and assays.
Isolated components found in the Saussurea controversa plant have antimicrobial and regenerative properties which could lead to a treatment for bone diseases.
A study has demonstrated how mutations in early colon cancer prevail and grow into malignancies, using fluorescent imaging.
Researchers will create the first human heart-in-a-jar to study heart failure, identify new therapeutic targets and test novel treatments.
Researchers have discovered the existence of tendon stem cells, which could lead to improvements in treating tendon injuries, avoiding surgery.
We present cell retention technologies suitable for small and bench scale bioprocessing.
From small-scale stem cell production to large-scale hiPSC-based drug development: The flexibility of stirred-tank bioreactors.
A major step has been taken towards developing functional miniature versions of human organs in a Petri dish which can be used to shed light on the processes involved in the genesis of diseases.
Researchers have discovered a potential new strategy for treating myelodysplastic syndrome, which has shown to be successful in pre-clinical trials.
