SARS-CoV-2 RNA analysis reveals potential treatment targets
Researchers have explored the interaction between SARS-CoV-2 RNA and the host cell, uncovering possible targets to prevent viral replication.
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Analogue of psychedelic ibogaine reverses effects of stress in mice
Tabernanthalog (TBG), similar to the psychedelic drug ibogaine, corrected stress-induced behavioural deficits in mice.
Researchers synthesise potential anticancer compounds
Scientists have developed six new derivatives of 4-chloro-1,2-dithiol-3-thione, which have all demonstrated anticancer effects in pre-clinical studies.
WHO and Switzerland launch BioHub for pathogen storage and analysis
The WHO and Swiss Confederation are set to launch a BioHub Facility, intended to facilitate the sharing of pathogens globally.
GRP78 molecular chaperone revealed as drug target for COVID-19
Using computer modelling, a team has shown that a molecular chaperone called GRP78 could be targeted by drugs in strategies to treat COVID-19.
Nanoparticle flu vaccine shows promise at protecting mice
Using nanoparticle liposomes, researchers have developed an experimental flu vaccine that has shown success in pre-clinical studies.
Microtitration assay developed to detect Ebola virus in vitro
Researchers have successfully created an unbiased, high-throughput microtitration assay for the quantification of Ebola virus in cell lines.
Potential SARS-CoV-2 antiviral to be tested in human lung cells
A synthetic antiviral named R327 has shown promise in initial tests against SARS-CoV-2 and is now advancing to the next stage of in vitro studies.
Scientists identify protein drug target to potentially treat cataracts
Researchers have shown that a protein named aquaporin can disrupt optical development, leading to cataract formation.
High-throughput screening assay developed to discover antimalarials
A new assay has been developed to screen for small molecule inhibitors of the Rh5 protein, which is essential for malaria parasite survival.
Computational modelling reveals SARS-CoV-2 mutation ‘hotspots’
A new modelling method could be used as a surveillance tool to monitor emerging infectious SARS-CoV-2 variants, scientists say.
Genomic analysis reveals cellular cause of type 1 diabetes
Combining two genomic methodologies, researchers have shown that pancreatic exocrine cells are implicated in type 1 diabetes.
New synthetic biologic could treat obesity-related diseases
A synthetically made glycopeptide biologic has shown promise as a treatment for obesity-related diseases in mice.
Potential COVID-19 antiviral formulated with siRNA-nanoparticles
Scientists have created an antiviral therapy using lipid nanoparticles that deliver siRNA to the lungs to treat COVID-19 in mice.
Novel method of labelling DNA bases developed for sequencing
Using electrochemical detection and redox labels, researchers have created a new, faster method to sequence DNA.
