PJ34 triggers self-destruction of human pancreatic cancer cells
A study conducted on human pancreatic tumours transplanted in mice reveals promise for an effective therapy in the future, say researchers.
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Researchers must not rely on generic online searches for chemical probes, study finds
The ICR has revealed that during drug discovery, researchers should not use general search engines and vendor catalogue information to decide on their use of chemical probes.
Protein tag developed to aid in study of the immune system
A novel approach to better understand a basic defence mechanism of the immune system has been developed using the ISG15 protein which could lead to novel antimicrobial drugs.
Researchers use imaging to reveal early stages of colon cancer
A study has demonstrated how mutations in early colon cancer prevail and grow into malignancies, using fluorescent imaging.
Direct link shown between inflammasome activation and Alzheimer’s
A new study has demonstrated that NLRP3 inflammasome directly drives tau pathology in neurodegenerative diseases and Alzheimer's disease.
Animal model market set to grow to $24bn by 2025
New research has found that the animal model market for disease research and therapeutic testing will exhibit strong growth.
Novel pathway to target colorectal cancer identified
Researchers have found that PGE2, a signalling molecule involved in inflammation, promotes colorectal cancer progression through a microRNA and targeting that microRNA could have therapeutic potential.
Restarting metabolic process could make sarcoma susceptible to treatment
Researchers have found that soft tissue sarcoma cells stop a key metabolic process which allows them to spread and restarting that process could leave these cancers vulnerable treatments.
Phage-enriched mucosal surfaces could combat bacteria infections
Researchers have found that, in rainbow trout models, phages on mucosal surfaces infect pathogenic bacteria, providing protection.
Dengue vaccines may be improved by simulating amino acid starvation
Scientists have discovered that a plant-based compound called halofuginone activates a pathway that results in better antibodies and could improve the effectiveness of vaccines.
Fruit fly model to study mitochondrial diseases developed
Researchers have created ‘three-parent flies' which can be used as a model to study mitochondrial diseases and screen potential drug compounds.
Protein therapeutic development could be accelerated with new method
Scientists have developed a new method that accelerates the design and engineering of potential medicines and vaccines using glycosylation.
Researchers develop vaccine with potential to treat pancreatic cancer
A study has demonstrated that a novel vaccine design for pancreatic cancer has been successful in mice, doubling survival time.
Human heart-in-a-jar model to be developed
Researchers will create the first human heart-in-a-jar to study heart failure, identify new therapeutic targets and test novel treatments.
Fungi library could aid in the search for medical drugs
A library of products derived from more than 10,000 fungi has been established which could lead to the discovery of new drugs.
