news
Inexpensive drug protects against COVID-19 inflammation in pre-clinical trials
A drug called topotecan (TPT) was administered to mice up to four days after COVID-19 infection, reducing inflammation and morbidity.
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Drug Development
article
Synthesising very long-chain fatty acids to treat retinal conditions
A class of lipids – or fatty acids – found in the retina of the eye play an important role in maintaining vision. Victoria Rees, Deputy Editor of Drug Target Review, spoke with Dr Paul Bernstein from the Moran Eye Center at the University of Utah, US, to discover how…
article
Which CHO cell is the right CHO cell?
Dr Louis Boon offers guidance on how to select the best CHO cell for the upstream bioprocessing of biologics. He also explains how automation can aid monoclonality and why the most efficient approach during the development of biological drugs is to utilise an established cell line platform.
whitepaper
Product hub: The world’s first BioPharma Lifecycle Management system – navigating your biopharma lifecycle
Here, we present IDBS Polar, a platform that securely manages drug progression in contexts of workflow, integration and insight.
news
Antibodies and remdesivir used to treat Marburg virus in rhesus macaques
The combination of mAbs and remdesivir induced an 80 percent protection rate against Marburg virus in rhesus macaques, according to a new study.
podcasts
Episode 1 – Dr Sri Gopal, Janssen Pharmaceuticals
Listen along to learn more about drug development for schizophrenia from Dr Sri Gopal, Head of Psychiatry R&D for Janssen!
news
Three common antiviral drugs effective against SARS-CoV-2 in vitro
A team has shown that tilorone, quinacrine and pyronaridine are effective at inhibiting the replication of SARS-CoV-2 in vitro.
news
Organ-on-a-chip model developed to aid sickle cell disease treatment
Researchers have developed a novel organ-on-a-chip model of sickle cell disease to improve personalised medicine.
article
Identifying a novel treatment for heart attacks
Professor David Merryman explains how his team targeted the serotonin 2B receptor in animal models to preserve cardiac function six weeks after a heart attack.
news
Unpredicted binding found between SARS-CoV-2 and hepatitis C drug, telaprevir
Insights into the interaction between telaprevir and the SARS-CoV-2 main protease could aid in future COVID-19 drug design, say scientists.
news
Lung-on-a-chip models enable advanced study of immune response
Researchers have reviewed lung-on-a-chip technologies, finding they are useful for representing the various disease pathologies.
news
Polymerised oestrogen provides neuroprotection in pre-clinical study
The polymerised form of oestrogen has shown success in mice at preventing further damage to the spinal cord after injury.
news
Cannabinoids could reduce essential tremors in patients
A synthetic cannabinoid has shown promise as a treatment for involuntary tremors by activating astrocytes in mouse models.
article
A strategy to cloak gene therapy AAV vectors from immune responses
Dr Ying Kai Chan discusses his latest research into how the delivery of AAV vectors for gene therapies can be made safer and more effective.
news
Researchers gain insight into metabolic pathways hijacked by SARS-CoV-2
SARS-CoV-2 diverts building blocks from glucose production to the assembly of purine bases, researchers have found.
