Drug Discovery

New drug could be used for targeted cancer therapies

7 August 2019 | By Rachael Harper (Drug Target Review)

A new drug called IP1867B, which could be used for future treatments of brain tumours, is being examined.

New therapy discovered to treat acute lymphoblastic leukaemia

30 July 2019 | By Drug Target Review

Researchers have discovered a new combination therapy to treat drug-resistant acute lymphoblastic leukaemia, tested in pre-clinical trials.

Encouraging drug discovery and therapeutic targets for dementia

26 July 2019 | By Victoria Rees (Drug Target Review)

A review has been published by experts in neurodegeneration research, detailing six ways to improve dementia research. This article investigates one of these suggestions, focusing on how we can improve drug target identification.

Promising drug developed for ovarian and pancreatic cancers

22 July 2019 | By Drug Target Review

An antibody has been developed to block a protein secreted by the cells surrounding ovarian and pancreatic cancer tumours.

Crystals mapped to advance treatments for stroke, diabetes and dementia

5 July 2019 | By Drug Target Review

Researchers haved mapped the crystal structure of a protein to find out how a drug latches onto it.

Titian Software Ltd

Artificial intelligence in the world of drug discovery

4 July 2019 | By Victoria Rees (Drug Target Review)

Charlotte Walker-Osborn, a Partner and Head of Technology Sector (International) at global law-firm Eversheds Sutherland and a legal expert in technology law, explains some of the challenges and potential future of artificial intelligence (AI) in the field of drug discovery.

Study reveals vulnerability of common pathogenic viruses

13 June 2019 | By Victoria Rees (Drug Target Review)

Researchers have developed a stabilisation technique for widespread viruses, creating drug opportunity.

MS treatment potential after condition-causing genes identified

7 June 2019 | By Drug Target Review

Researchers have found 12 genes which cause MS, creating potential for preventative treatment of the condition.

Ten big pharma companies collaborate on data sharing AI

7 June 2019 | By Victoria Rees (Drug Target Review)

A new AI project marks the first time 10 pharmaceutical companies have agreed to share data to aid drug discovery.

Screening In-Depth Focus 2019

7 June 2019 | By Drug Target Review

This in-depth focus discusses screening and the uses of phenotypic profiling in drug discovery. Also examined is the role that CRISPR/Cas9 gene editing and native mass spectrometry play.

Phenotypic profiling in drug discovery

5 June 2019 | By Ina Rothenaigner, Kamyar Hadian, Sean Lin

Image-based phenotypic profiling of small molecules has been used for identification and characterisation of small molecules in drug discovery and can provide important insights into their mechanisms of action (MOA). This article discusses the use of phenotypic profiling in drug discovery and how machine-learning algorithms could help improve objectivity, processing…

AI-driven automated chemistry as a tool to accelerate drug discovery

15 May 2019 | By Alexey Zakharov (National Center for Advancing Translational Sciences)

Typically, early drug discovery campaigns start with the screening of chemical libraries to identify candidate chemotypes modulating a particular target and/or phenotype. Success of the primary screening depends on multiple factors related to both biology and chemistry. These include the target’s druggability, sensitivity and specificity of assay system, composition and…

Application note: Tools and protocols for high-content imaging and analysis

14 May 2019 | By Thermo Fisher Scientific

Integrating hardware, software and fluorescent labels for optimised HCA assay development.

Application note: Laser technology for high-content imaging and analysis

14 May 2019 | By Thermo Fisher Scientific

Introducing the CellInsight CX7 LZR High-Content Analysis Platform - an updated version of our CellInsight CX7 instrument with advanced laser technology.