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Dozens of anti-cancer compounds revealed by screening existing drugs
Researchers have screened thousands of existing drug molecules against cancer cell lines to discover almost 50 compounds that combat the condition.
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Drug Targets
A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.
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Researchers use CRISPR to identify proteins that prevent inflammation
New findings using CRISPR have shown that the IL-4 and IL-13 proteins can protect the body against inflammation from autoimmune diseases.
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Cell division recreated in a test tube demonstrates TPX2 protein role in cancer
Studies have identified that the TPX2 protein recruits the molecular machinery required for the branching microtubule nucleation process, so could be a target for cancer therapies.
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Levels of neurogenesis could be a therapeutic target in neurodegenerative disease
Research has identified that regions of the brain can regenerate via neural stem cells and the process of neurogenesis which could provide a new avenue for regenerative therapeutics.
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PCSK6 enzyme plays a key role in vascular disease, according to research
A new study has demonstrated that the enzyme proprotein convert subtilisin/kexin 6 causes structural and functional remodelling in vascular disease, so could be a new therapeutic target.
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Mutations in non-coding regions of the cancer genome could drive tumour growth
Research into the role of non-coding DNA in cancer development and progression has identified 30 regions that may contribute to tumour growth, which could be therapeutic targets.
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Researchers discover potential diet drug strategy without feeling of nausea
A study has revealed a brain circuit in mice that suppresses the need to eat without a feeling of nausea, presenting a new strategy for diet drugs.
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Metal-based fragment molecule library to screen for drug candidates
Researchers have developed a novel metal-based fragment library of molecules that can be used to screen for new drug candidates.
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Could novel sex-linked targets provide an autoimmunity therapy?
Recent research into why autoimmune disorders affect women four times more frequently than men has revealed several novel therapeutic targets that may lead to the development of future treatments.
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New capillary model could provide new therapies for malaria
Researchers have produced a capillary model which allows investigation of the dynamics of blood flow obstruction in real scale and could be used to test new therapies for P. falciparum malaria.
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Researchers discover α-synuclein clue to treating Parkinson’s
A study has shown that fruit fly larvae lacking a certain region of the α-synuclein protein did not exhibit Parkinson’s symptoms, indicating a potential target.
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MLL gene key to producing hematopoietic stem cells, says research
Researchers investigating childhood leukaemia have discovered that increasing MLL gene expression in iPSCs drives hematopoietic stem cell production, so could be the target of new therapies.
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Researchers find VISTA molecule silences immune system against cancer
A new study shows that the VISTA molecule stops the immune system responding to self-antigens, including those presented by cancer cells, so an anti-VISTA antibody could be a possible therapy.
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Endometriosis symptoms in mice improved by cannabinoids
A new study in mice has suggested that cannabinoids can relieve pain caused by endometriosis and paves the way for further clinical research.
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DIRC3 tumour suppressor could be a new target for melanoma therapies
A study has shown that long non-coding RNA called DIRC3 can block melanoma growth and could be used to identify new targets for skin cancer therapies.
