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Enzyme found to be an “Achilles’ heel” in ovarian cancers
Scientists have uncovered the crucial role of the enzyme NMNAT-2 in ovarian cancers, as well as other biomarkers that could lead to treatments.
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Enzymes
Enzymes are macromolecular biological catalysts. Enzymes accelerate, or catalyse, chemical reactions.
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Inhibiting PIP4K enzymes could help immune system fight cancer
Researchers identified a potential therapeutic involving the inhibition of PIP4K enzymes which could enable the immune system to destroy tumour cells.
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Metabolic pathway could potentially enhance vaccine effectiveness
A metabolic control pathway that regulates T follicular helper cells could enhance vaccine effectiveness, including those that protect against COVID-19.
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Promising new avenue to tackle obesity-related diabetes
New findings from collaborative research in the United States have identified a promising new treatment avenue for type 2 diabetes patients centring on the activity of the amino acid, GABA.
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Lipid droplets may prevent kidney damage from high-fat diets
Researchers have shown in fruit flies that lipid droplets could prevent the kidney damage that leads to chronic kidney disease.
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Mitochondrial enzyme found to block ferroptosis, presenting cancer target
The mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) can block cell death, new research has shown, making it a cancer drug target.
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Inhibiting METTL3 enzyme combats acute myeloid leukaemia in mice
Scientists have developed a drug called STM2457 which inhibits a key enzyme involved in acute myeloid leukaemia.
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Researchers develop new biosynthesis process to create antibiotics
Scientists have discovered that manipulating residues enables precision during the antibiotic biosynthesis assembly line.
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Team reveals miR-29 as regulator of processes for normal brain maturation
Researchers have shown that miR-29 can control brain maturation in mammals, presenting a target for autism, epilepsy and other conditions.
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Deactivating gene could boost immunotherapy for head and neck cancer
Inhibiting the KDM4A enzyme slowed the growth of head and neck cancer in mouse models, also demonstrating promise to aid immunotherapy.
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Study identifies potential drug target for treating COVID-19
Researchers have shown that the PLpro coronavirus enzyme presents a possible target in the fight against COVID-19.
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Researchers reveal how key enzyme APT2 works in cells
Using X-ray crystallography and simulations, researchers have shown that APT2 is a hybrid between a lipid carrier protein and a hydrolase.
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Developing bioenergetic nanocatalysts, a novel approach to treat neurodegeneration
Mark Mortenson, CSO of Clene Nanomedicine, discusses the use of proprietary gold nanocrystals as catalysts to prevent the progression of, and act as a treatment for, neurodegenerative disease.
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SARS-CoV-2 model shows Spike protein co-operation
A new coarse-grained model of the complete SARS-CoV-2 virion has revealed potential new ways to combat the coronavirus.
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Researchers find MAPK4 enzyme presents target for prostate cancer
Research has shown that MAPK4 activates two molecules in cellular signalling pathways involved in prostate cancer growth.
