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pGENMi predicts genomic features associated with drug responses
A new system, pGENMi, could predict genomic features associated with drug responses, by identifying differences in gene expression...
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Epigenetics
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Administering hormones affects DNA
In an experiment with pigs, researchers have demonstrated for the first time that the administration of even extremely low doses of an endocrine disruptor - in this case, an endogenous oestrogen - leads to epigenetic changes in a pregnant sow’s DNA.
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Breast cancer could be prevented by targeting epigenetic proteins
Researchers have discovered that epigenetic proteins promote the proliferation of mammary gland stem cells in response to the sex hormone progesterone.
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New epigenetic drug against Mantle Cell Lymphoma
A new study presents an epigenetic drug capable of slowing down cell growth in Mantle Cell Lymphoma (MCL)...
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ISSCR 2018 to highlight research driving new discoveries and advances in regenerative medicine
Progress in stem cell research and its translation to medicine is the focus of the International Society for Stem Cell Research annual meeting 20-23 June at the Melbourne Convention & Exhibition Centre in Melbourne, Australia.
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Researchers in Spain elucidate complete epigenome for leukaemia
A team of researchers in Spain show for the first time the complete epigenome of chronic lymphocytic leukaemia, the most common type of leukaemia.
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Penn study finds that different diseases elicit distinct sets of exhausted T cells
Using data from multiple molecular databases, researchers from the University of Pennsylvania have found nine distinct types of exhausted T cells (‘Tex’), which could have implications for fighting chronic infections, autoimmunity, and cancer.
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A link between Huntington’s disease and rheumatoid arthritis identified
Epigenomic analyses may lead to other unexpected findings and novel therapeutic drug targets for many diseases
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KLF14 gene may increase risk of type 2 diabetes
Scientists have identified a gene that in women is linked to the creation and location of new fat cells and therefore is thought to contribute to the risk of type 2 diabetes...
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Kenpaullone protects from cisplatin-induced hearing loss
Researchers have discovered that inhibiting an enzyme called cyclin-dependent kinase 2 protects mice and rats from noise- or drug-induced hearing loss...
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Depleting BACE1 reverse the formation of amyloid plaques in Alzheimer’s disease
A team of researchers from the have found that gradually depleting an enzyme called BACE1 completely reverses the formation of amyloid plaques in the brains of mice with Alzheimer's disease...
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Molecular therapy restores nerve insulation on peripheral nerves
Scientists have described an experimental molecular therapy that restores insulation on peripheral nerves in mice, improves limb function, and results in less observable discomfort...
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DNMT3A crystal structure linked to cancer development
Scientists offer important information for understanding de novo DNA methlylation...
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SMi’s 9th annual RNA Therapeutics conference will take place in just 2 weeks!
Presenting issues and real-life examples within the RNA space, SMi welcome insights and discussions into new technologies for single-stranded RNA, epigenetics to develop first-in class drugs in oncology, patenting RNA Therapeutics and exploring the latest developments in delivery systems, including Exosomes and Nanocomplexes. Read on for your exclusive discount to…
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Study uncovers therapeutic targets for aggressive triple-negative breast cancers
New findings have made inroads into a strategy to identify TNBC tumours at risk for metastasis...
