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Research reveals CDH17 represents a new approach to treat solid cancers
Pre-clinical research has found that CAR T cells can suppress gastrointestinal cancer cells without causing harm to healthy tissues.
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Immunotherapy
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CAR T-cell implant effective at attacking cancer in pre-clinical study
Researchers have created an implantable biotechnology that produces and releases CAR T cells for attacking cancerous tumours.
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New potential therapy developed in response to bladder cancer
Research in mice has shown that adding anti-inflammatory medication to immunotherapy and standard chemotherapy drugs may provide long-term suppression of aggressive bladder tumour growth.
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Promising potential therapeutic strategy against pancreatic cancer developed
Scientists have discovered a new strategy that can make pancreatic tumours visible to the immune systems of mice and vulnerable to immune attack.
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Enhanced way to generate effective personalised cancer vaccines revealed in study
Scientists have created a pipeline for identifying, prioritising and evaluating potential tumour antigens for personalised cancer vaccines.
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Pre-clinical study shows significant increase in effectiveness of breast cancer immunotherapy
Scientists have discovered the essential role of a ligand-dependent corepressor to potentially enable cancer cells to present tumour antigens on their surfaces.
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Study provides possible answers to why immunotherapy for ovarian cancers often fails
New research has discovered metabolic mechanisms that contribute to how ovarian cancer escapes from immune attack and how combination therapies can exploit these pathways to improve ovarian cancer treatment.
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Enzyme revealed as promising new target for cancer immunotherapies
A new study has highlighted an enzyme called ART1 as a promising target for immunity-boosting cancer treatments.
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New findings could improve personalised cancer immunotherapies
A new study has highlighted that gene expression profiling could enable rapid identification of anti-tumour immune cells for personalised immunotherapy.
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Tool developed to fight cancer rapidly and effectively
Scientists from Northwestern University have developed a new technology platform that could bring individualised cell therapies to cancer patients.
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Discovery could advance CAR T-cell therapy
Scientists have found a way to “supercharge” tumour-attacking T cells, which could improve the effectiveness of cell-based cancer immunotherapy and expand the number of cancers it can treat.
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Improved way to generate breast tumour models
Researchers have developed a new way to generate breast tumour models faster, more reliably and with less immune variability than existing models.
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Novel CAR T-cell therapy for B-cell cancers shows promise in vivo
A new CAR T-cell therapy for B-cell cancers promises to reduce the antigen escape currently found in therapies that only target CD19.
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Drug Target Review Flow Cytometry ebook 2021
This ebook includes articles on flow cytometry in drug discovery and how it is applied to leishmaniasis research. Also included is a piece on how flow cytometry is being used to support the translational research of immuno-oncology therapies.
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“Off-the-shelf” immunotherapies for cancer
In this article, Drug Target Review's Victoria Rees explores a new method that could enable powerful immune cells to be produced in large quantities to treat a range of cancers.
