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Could a sphingosine nasal spray prevent COVID-19?
According to a study, the lipid sphingosine can inhibit SARS-CoV-2 infection and could potentially be delivered in a nasal spray to prevent COVID-19 infections.
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How do general anaesthetics cause loss of consciousness?
Inhaled general anaesthetics have been used for over 100 years and continue to be used daily for surgeries around the world. But how do they induce changes to consciousness? This article explores the research that suggests the anaesthetics chloroform and isoflurane disrupt the organisation of lipid rafts within cellular membranes…
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Application note: Improving High Throughput AlphaLISA® with The TEMPEST®
Using TEMPEST®, St. Jude Children’s Research Hospital were able to rapidly screen a focused compound library for early cancer drug candidates in an AlphaLISA® assay.
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Lipid mediators suggested as potential COVID-19 inflammation treatment
A new article has outlined the body's inflammatory response to COVID-19 infection, saying that lipid mediators derived from omega-3 fatty acids could prevent life-threatening inflammation.
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Software developed by researchers accelerates analysis of lipids
A novel software made by scientists can be used for the analysis of specific lipid groups and lipid signal molecules which can enable their characterisation with mass spectrometry.
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Chemical tool developed to examine lipids in living cells
A new method has been developed by researchers using chemical tools activated by light to influence lipid concentration in living cells.
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Structure of lipin enzyme responsible for triglycerides revealed for first time
Researchers have obtained the crystal structure of the lipin enzyme, the regulator of triglyceride production, which they say could inform research into heart disease, obesity and diabetes.
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Farther than fat: how lipids change research
Today we are beginning to realise that lipids have been inadequately represented in biological and medical research. For decades, studies in the fields of DNA and proteins have been pushed but despite these adverse conditions, lipid research has made pioneering discoveries over the course of the last seven years. These…
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Drug Target Review – Issue 1 2019
In this issue: AI-driven automated chemistry as a tool to accelerate drug discovery processes, the shifting landscape of immuno-oncology, and how lipid molecules provide an insight into biological research.
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13th International Conference on Metabolomics and Systems Biology
Euro Metabolomics 2018 will be a platform to investigate on recent research and advancements that can be useful to the researchers.
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How the study of lipidomics is benefiting from recent advances in mass spectrometry
There are no short-cuts in the complex field of lipidomics, explains Cristina Legido-Quigley, a Principal Investigator in Systems Medicine at Steno Diabetes Center Copenhagen in Denmark and at King’s College London.
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Alzheimer’s patients exhibit changes in certain blood lipids typical of premature ageing
Research at MedUni Vienna’s Centre for Brain Research has investigated changes in certain lipids (choline phospholipids) in the plasma of elderly people who were healthy and those suffering from Alzheimer’s disease.
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Drug Target Review – Issue #1 2018
In this issue: how customised cell engineering advances immunotherapy, how insights into auto-immunity are providing new opportunities for immune-oncology, and advances in lab automation and robotics are accelerating the pace of antimicrobial therapy.
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Controlling ceramides could help treat lipotoxic cardiomyopathy
Study of Drosophila links ceramide accumulation to heart dysfunction...
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Lipid asymmetry plays key role in activating immune cells
Researchers have shown that by preventing loss of membrane asymmetry it's possible to control the immune response...