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Dysfunctional insulin release mechanism identified
A mechanism has been identified which regulates the release of insulin from β-cells and could be used to develop new treatments for type 2 diabetes.
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Training and development in flow cytometry and other core technologies
There is still much to be done regarding how training is delivered and monitored in core technologies such as flow cytometry. Here, Derek Davies outlines the approaches his team at The Francis Crick Institute are taking to train users of such technologies to ensure quality data is obtained and best…
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Structure of crucial metabolic enzyme revealed by high-end microscopy
Scientists reveal the atomic structure and regulative mechanism of the metabolic enzyme transhydrogenase.
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CRISPR-Cas9 gene editing imaged for first time
Researchers have generated images of CRISPR-Cas9 gene editing for the first time, enabling improvement of the technique.
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Norovirus structure imaged, providing potential for vaccine development
Researchers have been able to image noroviruses, providing significant information for the development of therapeutics.
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Study identifies novel lupus drug target
Structure of internal regulator molecule identified, presenting lupus drug potential.
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Drug Target Review – Issue 1 2019
In this issue: AI-driven automated chemistry as a tool to accelerate drug discovery processes, the shifting landscape of immuno-oncology, and how lipid molecules provide an insight into biological research.
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New imaging platform successfully tracks Gram-negative bacterial lung infections
A team of scientists in the UK have developed a fluorescent imaging probe capable of tracking Gram-negative bacterial lung infections in real time.
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Enhanced 3D neuron imaging could diagnose brain disease
Researchers have combined an open source software programme and commercially available hardware to image neuron activity at high resolution...
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Exploring horizons in 3D microscopy: what the future holds
The microscope slide is flat (2D), but the world around us is not – despite the flat-earth theories. We need volume information about our samples, ideally with high resolution in all three dimensions as well as over time – the fourth dimension...
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New 3D ‘nanoscope’ facilitates improved brain imaging for Alzheimer’s research
Scientists in the U.S. have developed a powerful imaging tool to more accurately reproduce visuals of the brain and investigate mechanisms that precede Alzheimer’s symptoms.
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New evidence sheds light on how Parkinson’s disease may happen
Researchers at Baylor College of Medicine and Texas Children’s Hospital have identified unexpected new key players in the development of an early onset form of Parkinson’s disease called Parkinsonism.
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Link found between neurotransmitter imbalance and brain connectivity in those with autism
Researchers have identified a link between a neurotransmitter imbalance and brain connectivity between regions of the brain that play a role in social communication and language.
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Collaborative team first to identify the perinexus in the human heart
A collaborative research team is on a quest to collapse a tiny pocket between cardiac cells, called the perinexus.
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Scientists decode ASCT2 protein as possible cancer drug target
Scientists in the Netherlands have investigated the structure of the human glutamine transporter ASCT2 in a bid to generate leads for cancer drug development.
