news
Regeneration mechanism could provide target for liver disease drugs
A newly-discovered molecular mechanism that allows damaged adult liver cells to regenerate could pave the way for drugs for chronic liver diseases.
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Molecular Biology
news
Weapon bacteria could be copied to create new forms of antibiotics
New antibiotics could be designed by discovering the mechanism a weapon bacteria uses to vanquish their competitors.
news
T cell homing beacons for lungs identified by researchers
Molecules that are critical for T cells to travel to and populate the lungs have been identified which could strengthen vaccines against influenza.
news
Dysfunctional insulin release mechanism identified
A mechanism has been identified which regulates the release of insulin from β-cells and could be used to develop new treatments for type 2 diabetes.
news
New target for regulating mitochondria during stress identified
A new target has been identified for the treatment of heart failure, heart attack, stroke and neurodegeneration.
article
Designing proteins from scratch with computer science
Marc Baiget-Francesch highlights interesting developments in the field of protein drug design and explains how continual software improvements are speeding up the process.
news
Molecule discovered that regulates development of tumours
Researchers discover that a non-coding region of the genome originates a key molecule for the proliferation of cancerous tumours.
article
Bringing native analysis into the fast-moving world of biologics
For the past thirty years, native mass spectrometry has grown in both scope and reach in labs across the globe to encompass larger and more challenging molecular complexes. However, up until now, the throughput of these techniques has been slow and manual. Christopher Nortcliffe discusses ways that native analysis is…
news
Therapeutic strategy to prevent gastrointestinal disease
New approach restores epithelial function in diarrhoea and inflammatory bowel disease models...
webinar
Phenotypic screening using iPSC-based human disease biology
18 February 2019 | By Tecan and Ncardia
Ncardia, will discuss the application of human iPSC-derived cell-based assays and high throughput screening for drug discovery and development.
news
Genetic study reveals possible new routes to treating osteoarthritis
Scientists discover new genes and biological pathways linked to osteoarthritis, which could help identify starting points for new medicines...
news
‘Hidden pocket’ could be targeted to treat strokes
Researchers have identified a tiny hidden pocket on the NMDA receptor that could be targeted to treat strokes and seizures...
article
New frontiers in G protein-coupled receptor drug discovery
G protein-coupled receptors (GPCRs) are seven transmembrane spanning proteins that mediate the physiological responses to a broad array of stimuli, including photons, biogenic amines, peptides and large proteins. They represent the target of approximately one-third of all approved drugs,1 yet paradoxically remain a relatively under-exploited protein class.
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Webinar highlights: Recent advances in diagnostics and treatments – from small molecules to cellular therapies
The webinar presented an overview of the pre-clinical milestones, the current status of the global drug pipeline and a description of a number of novel drugs undergoing clinical trials.
whitepaper
Application note: A novel solution to expedite antibody discovery
With breakthroughs in molecular engineering and antibody humanisation, monoclonal antibodies (mAb) are one of the fastest-growing classes of biopharmaceuticals for multiple clinical indications including cancer, cardiovascular disease, autoimmune disorders and infectious disease. Most therapeutic antibody candidates are initially generated using hybridoma technology or primary B-cell screening after antigen immunisation.
