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Researchers map pathoconnectome of eye disease and retinal circuitry
Scientists have produced the first pathoconnectome - an open access map for other researchers that shows how eye disease can alter retinal circuitry.
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Stem cell therapy repairs Parkinson’s degeneration in mice
Researchers demonstrate that transplanting dopaminergic neurons grown from stem cells into the brains of mice improved motor skills.
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How do general anaesthetics cause loss of consciousness?
Inhaled general anaesthetics have been used for over 100 years and continue to be used daily for surgeries around the world. But how do they induce changes to consciousness? This article explores the research that suggests the anaesthetics chloroform and isoflurane disrupt the organisation of lipid rafts within cellular membranes…
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Psychedelic drug discovery enabling discovery of new psychiatric drugs
Having resolved the structure of psychedelic drugs bound to the 5-HT2A serotonin receptor researchers are now developing new therapeutic drugs.
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A novel drug target for viral encephalitis therapies
Researchers showed CXCL1 signalling to neutrophils drove brain inflammation in herpes simplex virus (HSV) encephalitis and blocking the protein resulted in less severe disease.
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Cocaine and the brain: identifying targets for addiction therapies
There are currently no licenced pharmaceuticals to treat cocaine addiction. To overcome this issue, US researchers at the University of Alabama at Birmingham have been exploring how cocaine alters transcription in the nucleus accumbens, a region of the brain implicated in compulsive drug use. Here, Hannah Balfour discusses with Dr…
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Novel molecule restores lost connections in spinal cords and brains of mice
Researchers have developed a molecule that can restore lost connections in the spinal cords and brains of mice with cerebellar ataxia, Alzheimer's disease and spinal cord injury.
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Stem cells used to identify potential treatments for Parkinson’s disease
Scientists have found two active substances that allowed cells to reactivate the production of a protein that prevents the onset of Parkinson's disease.
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Exploring new drug targets in Alzheimer’s disease
Although many potential targets have been identified for Alzheimer’s disease (AD), there is no effective treatment for this debilitating condition. In this article, Monika Schmidt and Sheraz Gul delve into the key proteins implicated in AD and suggest how phenotypic assays could aid in AD drug discovery.
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Study shows how cone cells in the retina form connections with brain
Researchers have discovered how cone cells in the retina send information to the brain, which could be used in the development of treatments for blindness.
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Astrocytes likely contribute to Parkinson’s disease progression
A new study shows astrocytes derived from monogenic Parkinson’s patients have metabolic alterations that mean they could be contributing to disease progression.
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Mutation in n-Tr20 gene found to disrupt neurotransmission in brain
Researchers have shown that a mutation in the n-Tr20 gene can alter brain function and behaviour, while loss of the gene made mice resistant to seizures.
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Researchers halt type 1 diabetes onset by denervating the pancreas
Scientists denervated the pancreas using surgery or pharmacological agents to protect it from immune-mediated beta cell destruction, preventing the onset of type 1 diabetes.
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Novel alpha-synuclein structures could be the target for future Parkinson’s therapies
Researchers observed new structures of alpha-synuclein aggregates in their study exploring how the presence of cell membrane phospholipids impacts protein aggregation.
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Researchers identify promising drug target for Huntington’s disease
Researchers have found the TBK1 enzyme regulates the degradation and clearance of the huntingtin protein, making it a drug target for Huntington's disease.
