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A novel target revealed for myelodysplastic syndrome
Researchers have discovered a potential new strategy for treating myelodysplastic syndrome, which has shown to be successful in pre-clinical trials.
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Oncology
Oncology is a branch of medicine that deals with the prevention, diagnosis and treatment of cancer.
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Novel metabolic-focused high-throughput screening method developed
Researchers have created a new high-throughput screening system which could identify new drugs by focusing on nucleotide metabolism.
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Mitocans partner up to provide powerful leukaemia treatment
A pioneering team of scientists from Rice University has discovered that a particular combination of chemotherapeutics, including mitocans that target mitochondria, form a powerful treatment for acute myeloid leukaemia patients.
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Function of protein involved in liver cancer discovered
The involvement of clathrin in the development of liver cancer has been described for the first time, which could lead to more targeted therapy.
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SEL120: a promising CDK8 kinase inhibitor
A novel CDK8 inhibitor has been developed by scientists at Ryvu Therapeutics. Dr Krzysztof Brzozka showcases this molecule and explains the R&D behind it.
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Researchers reveal how body repairs damaged DNA
A team has imaged the process that the body uses to stabilise DNA, which could be used to develop therapies for conditions such as cancer.
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Reasons why targeted immuno-oncology drugs sometimes fail discovered
A new study has shown the specific cellular mechanisms that limit the ability of CD8 T cells to infiltrate the tumour microenvironment, which could guide new immunotherapeutic strategies in cancer.
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Study reveals how circulating tumour cells target organs
Regulator genes and proteins have been identified on circulating tumour cells in mice which allow them to target other organs in the body.
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Silencing RNA nanotherapy shows promise in treating pancreatic cancer
Peptide-based nanoparticles have been designed which can suppress pancreatic cancer growth without the toxic side effects.
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New way to target treatment-resistant cancers identified
A new mechanism by which cancer cells become resistant to chemotherapy has been found which could lead to a new target for drugs.
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Making tumour cells stiff could prevent cancer metastasis
A study has demonstrated that the stiffness of cells indicates whether a tumour will spread and inducing this state could help to avoid metastasis.
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Selective inhibitor could reduce resistance to cancer therapies
A study has found a selective inhibitor for an enzyme that allows cancer cells to mutate and become resistant to treatments.
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Researchers develop new immuno-oncology technique
A team has used viral gene editing and CRISPR to form a system that marks tumours for destruction, potentially improving immunotherapies.
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Cancer-suppressing cells identified in pancreatic cancer
Cells containing Meflin play a role in restraining the progression of pancreatic cancer and could lead to new therapies against the disease.
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3D tissue models of brain tumours created in brain-mimicking environment
A new platform has the potential to better understand what dictates the invasive behaviour of brain tumours.
