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Targeted therapy for treatment-resistant breast cancer
US researchers have uncovered a potential target for treating breast cancer that is resistant to endocrine therapies because of a specific gene mutation.
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Proteogenomics
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Understanding molecular mechanisms behind breast cancer
Oestrogen receptors play a crucial role in breast cancer. By making them therapeutic targets, oestrogen can be regulated with the aim to prevent breast cancer.
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What do cancer cells crave?
US researchers uncover the amino acid: arginine, that prompts genetic mutations in cancer cells.
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Molecular insights into LSCC may lead to new drug targets
New insights into lung squamous cell carcinoma (LSCC) have emerged from a proteogenomic study, leading to the identification of potential drug targets.
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Researchers uncover insights into pioneer transcription factors
A research team has discovered how proteins called pioneer transcription factors turn on vital genes in cells.
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Tweaking synonymous sites for gene therapy and vaccines
Professor Laurence D Hurst explains why understanding the nucleotide mutations in viruses, including SARS-CoV-2, can have significant implications for vaccine design.
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Proteogenomic analysis offers insights into paediatric brain tumours
The first comprehensive survey of genomics, transcriptomics, global proteomics and phosphoproteomics has revealed insights into paediatric brain tumours.
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Over 200 molecules and genes linked to COVID-19 severity
A team has identified 219 molecules and genes that influence the severity of COVID-19 in patients, providing information that could aid the development of therapeutics.
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Genetic analysis reveals disease-causing protein drug targets
An analysis of blood protein levels has supported drug target prioritisation by identifying the causal effects of proteins on diseases, a team has shown.
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Drug Target Review – Issue 3 2020
This issue includes articles that explore how a next-generation genomics platform can be used for COVID-19 research, the elimination of neutralising AAV antibodies for gene therapies and a new quick and cost-effective biomarker technology for cancer diagnostics. Also in this issue are features on antibody therapeutics for COVID-19 and targets…
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Experiments with Marburg virus reveal novel antibody protective mechanisms
Researchers discovered the monoclonal antibodies of a convalescent Marburg infection patient bound to the glycoprotein and combatted infection in two novel ways.
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Deep learning network used to model protein complexes
A new study has developed a deep learning approach that analyses protein interactions, which could improve the design of drugs in the future.
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‘Ubiquitin clipping’ proteomics technique could be used as novel treatment
A new technique called ‘ubiquitin clipping’ has been created which could aid proteomics research and the development of new drugs for ubiquitination.
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Machine-learning model to analyse protein sequences
A machine-learning model has been developed to analyse protein sequences, giving an insight to their structure, function and phylogeny...
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Omics-informed drug target discovery in combating emerging infectious diseases
The catastrophic consequences of ever-increasing rates of death from infectious diseases demands new experimental strategies for drug target selection and drug design. Over the last decade, the pharmaceutical industry has been wounded by several issues including failure of drug-development programmes, burgeoning cost of drug development, increasing regulatory control, lack of…