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3D models developed by researchers to optimise protein design
A computational programme has been created by researchers to aid in the design of proteins for therapeutics, to predict interactions.
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Proteomics
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Coronavirus update: recent developments in vaccine research
Drug Target Review’s round-up of the latest developments in 2019 novel coronavirus (COVID-19 or SARS-CoV-2) therapeutics and vaccines.
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WDR74 protein identified as lung cancer and melanoma therapeutic target
Researchers have revealed that the WDR74 protein plays a key role in lung cancer and melanoma, including metastasis, indicating it may be a potential drug target.
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The fate of cancer is all down to particular proteins
Scientists in Japan have identified an important protein that can impact the course of cancer and its fate in the human body.
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Study identifies brain stiffness as crucial for neurogenesis
A research team has shown that a key difference between neurogenic and non-neurogenic tissues is cross-linking proteins causing stiffness, a discovery that could be used to create new brain injury therapies.
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New potential targeted therapy strategy for triple negative breast cancer
A study has shown that targeting the proteins mtp53 and PARP in triple negative breast cancer could inhibit tumour growth and provide a new treatment option.
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Researchers develop technique to map protein-drug interactions
A new method of melting proteins has allowed researchers to identify new potential drug targets by revealing protein-drug interactions.
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New route identified for tackling drug resistance in skin cancer cells
A new therapeutic route for combatting treatment-resistant cancer has been identified with the discovery that melanoma cells fight anti-cancer drugs by changing their internal skeleton.
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Deep learning network used to model protein complexes
A new study has developed a deep learning approach that analyses protein interactions, which could improve the design of drugs in the future.
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Antibody characterisation – an essential researchers’ resource
Central to reproducibility in biomedical research is the ability to use well-characterised and defined reagents. The CPTAC Antibody Portal serves as a National Cancer Institute community resource that provides access to many standardised renewable affinity reagents to cancer-associated targets and accompanying characterisation data. Nikki Withers spoke to Dr Tara Hiltke…
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Newly-discovered protein could play key role in fighting obesity
An unexpected finding about a protein that's highly expressed in fat tissue could lead to new approaches for addressing obesity and many other diseases.
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Protein decoy hinders progress of lung cancer growth in mice
Researchers have slowed the spread of a type of non-small cell lung cancer in mice by neutralising a protein that would otherwise cause tumour growth.
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Function of protein involved in liver cancer discovered
The involvement of clathrin in the development of liver cancer has been described for the first time, which could lead to more targeted therapy.
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Proteomic approach reveals metastatic melanoma resistance to therapies
A study has used a proteomic method to uncover why some melanoma tumours do not respond to immunotherapy, which could improve treatments.
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Researchers identify pancreatic cancer protein drug target
A protein that causes pancreatic ductal adenocarcinoma has been identified as a therapeutic target by researchers.
