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LiP-mass spectrometric analysis measures molecular interactions
Researchers have systematically analysed and quantified the interactions of all proteins with metabolites on the level of the whole proteome...
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Proteomics
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TIMP-1 protein plays role in reducing cancer’s spread
Researchers have found that the TIMP-1 molecule that helps regulate gene expression plays a big role in keeping us safe from the machinations of cancer...
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Alpha-4 beta-7 protein levels linked to HIV infection risk
Scientists have shown a relationship between the proportion of key immune cells that display high levels of alpha-4 beta-7 at the time of HIV infection and health outcomes...
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MSK1 protein keeps metastatic breast cancer cells dormant
A study has identified the genes involved in the latent asymptomatic state of breast cancer metastases...
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HIF-1 protein shows promise as a non-hormonal treatment for menorrhagia
Researchers have identified a key protein that could explain why heavy bleeding occurs during menorrhagia, paving the way for potential treatments that avoid the need to take hormones...
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G-CSF protein involved in cocaine addiction
Researchers have identified a protein produced by the immune system that could be responsible for the development of cocaine addiction...
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The combination of two proteins exerts a regenerating effect in Parkinson’s disease
Parkinson’s research has led to the development an experimental model that allows different stages of Parkinson’s disease to be reproduced.
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Human protein may aid neuron invasion by virus that causes hand, foot, and mouth disease
A human protein known as prohibitin may play a significant role in infection of the nervous system by EV71, one of several viruses that can cause hand, foot, and mouth disease.
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Industry-academic collaboration results in improved understanding of cancer cell regulation
A team of researchers from the University of Liverpool and AstraZeneca has made an important contribution to our understanding of cancer cell regulation, holding promise for improved future cancer treatment.
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F50/T50 combination provides artificial ovary prototype
A protein formulation based on fibrin resembles the architecture and rigidity of human ovarian tissue and could be used for ovary transplant...
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Identification of hits and leads for human African trypanosomiasis
Neglected tropical diseases (NTD) affect more than one billion people and new targets and drugs are needed to tackle these infections. The multi-disciplinary NMTrypI consortium has identified a number of different compound classes which could be effective against these diseases. This article reviews some of these compounds...
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New weakness found in most common childhood malignant brain tumour
A new weakness found in medulloblastoma could lead to more personalised medicine and improved treatment for some patients.
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FUNDC1 protein in cardiac muscle cells linked to heart failure
Reducing a protein found in the mitochondria of cardiac muscle cells initiates cardiac dysfunction and heart failure...
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Pancreatic cancer: specific protein promotes development of pancreatitis and tumours
A study has shown that disruption to cell autophagy is involved in the development of pancreatic cancer.
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Drug Target Review – Issue #4 2017
Issue 4 of Drug Target Review looks at artificial intelligence in drug discovery and features In-Depth Focuses on Screening, Hit to Lead and Informatics.
