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Molecular insights into LSCC may lead to new drug targets
New insights into lung squamous cell carcinoma (LSCC) have emerged from a proteogenomic study, leading to the identification of potential drug targets.
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Spatial genomic and transcriptomic imaging in drug discovery
In this interview, read about the compilation of a new high-resolution cell atlas of the mouse brain using spatial genomics and transcriptomics.
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Key hallmark of ALS is successfully reversed in laboratory
Scientists demonstrated how to reverse the incorrect localisation of three RNA-binding proteins in ALS, potentially leading to treatments.
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Sunlight shown to trigger DNA mutation that causes melanoma
New research found mutations that cause melanoma result from a chemical conversion in DNA fuelled by sunlight, undermining previous theories.
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Removal of RNA-binding protein improves leukaemia survival
Study shows that removing the protein IGF2BP3 slows cancer growth and increases chances of survival of rare types of leukaemia in mice.
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“Untreatable” cases of cystic fibrosis may be undermined by new therapy
An experimental drug suggests that therapy for currently untreatable cases of cystic fibrosis is “clearly achievable”.
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Algorithm helps find best drug targets for all COVID-19 variants
A new computer algorithm has identified highly conserved sequences in viral proteins that could make the best drug targets for COVID-19.
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Novel group of small molecules show promise against SARS-CoV-2
Researchers in Germany have identified 69 small molecules as binding partners for genomic RNA of SARS-CoV-2, possibly leading to new drugs.
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How engineered RNA binding proteins delivered in vivo by gene therapy could treat myotonic dystrophy
In this article, Dr Jim Burns discusses promising pre-clinical results of how a new platform could treat the root cause of many devastating genetic diseases including myotonic dystrophy type 1.
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New class of compounds found to block coronavirus reproduction
In cell cultures, a compound named STM2457 was shown to interfere with coronavirus replication, making it a potential treatment for SARS-CoV-2.
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Novel vaccine against coronaviruses protects mice from infection
A new mRNA-based vaccine has demonstrated success at protecting against multiple coronaviruses in pre-clinical studies.
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Application note: Effectiveness of CRISPR‑Cas9 using pools of synthetic crRNAs in high-content analysis screening experiments
Chemical synthesis of guide RNAs for CRISPR-Cas9 gene editing enables accurate and rapid production of CRISPR libraries and screening in an arrayed, one-gene-per-well fashion.
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Novel mRNA vaccine provides full protection against malaria in mice
A new mRNA vaccine based on the malaria circumsporozoite protein was shown to elicit a robust immune response in mice.
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Human cells can write RNA sequences into DNA, study shows
For the first time, scientists have found evidence that polymerase theta can write RNA segments back into DNA.
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New algorithm could make CRISPR gene editing more precise
Researchers have created an algorithm that can predict the efficiencies of guide RNAs for CRISPR, potentially making it more precise.
