![A microscopy image of Leptospira bacteria [Credit: Wunder et al. (CC BY 4.0)].](https://www.drugtargetreview.com/wp-content/uploads/Leptospira-bacteria.jpg)
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Attenuated vaccine could combat fatal Leptospira bacteria
A single vaccination with a mutated Leptospira bacteria prevented rodent models from developing leptospirosis, the most fatal type of zoonotic disease worldwide.
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Vaccine
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New method for rapid development of vaccines for pre-clinical tests
Using synthetic chemistry, researchers have fused hydrophobic adjuvants with water-soluble proteins to create a new type of vaccine.
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Artificial intelligence analyses how viruses evade the immune system
The natural language processing model trained using viral protein sequence data was able to predict promising targets for vaccines against HIV, influenza and coronaviruses.
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Nanoparticle vaccine could protect against multiple coronaviruses
A new protein-based nanoparticle vaccine protected mice against a variety of coronaviruses, researchers have shown.
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Revealed structure of diarrhoea virus could aid in vaccine development
Using cryo-electron microscopy, researchers have observed the structure of a diarrhoea enteric adenovirus to see how it can survive the stomach.
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Novel vaccine could counter dangerous effects of synthetic cannabinoids
In pre-clinical trials, researchers have shown that a new vaccine could combat the dangerous effects of synthetic cannabinoids.
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New drug may boost vaccine responses in older adults
Researchers have found that spermidine can ramp up autophagy and boost T-cell function, potentially increasing the protective effects of vaccines in older adults.
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One-step method developed to generate mice for vaccine research
Using CRISPR-Cas9, scientists have developed a new method for generating mouse lines for vaccine research in just a few weeks.
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Protein identified as potential target for leishmaniasis vaccines
New research has demonstrated in mouse models that the SHP-1 protein limits the capacity of dendritic cells, making it a target for a leishmaniasis vaccine.
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The Editors’ views: Drug Target Review’s 2020 round-up
The Junior Editors of Drug Target Review, Victoria Rees and Hannah Balfour, discuss some of the most noteworthy news and announcements from this year.
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Inhaled vaccine induces strong immune response in animal models
Scientists report their phage-based inhaled vaccine delivery system elicited a robust antibody response in both mice and non-human primates.
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Triggering an IgA response could increase COVID-19 vaccine efficacy
Two new studies suggest that SARS-CoV-2-specific IgA antibodies are more neutralising and therefore COVID-19 vaccines should encourage an IgA response.
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Application note: Accurate measurements on the Octet platform without added sample purification steps
Bioanalytical systems have rapidly developed over the past 10 years for lead selection during cell-line development. The advanced technologies for the timely and cost-effective screening of antibodies or vaccines involve consideration of quantitation, kinetics and other critical quality attributes (CQA).
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COVID-19 vaccine candidate is 96.4 percent effective in mice, study shows
Administering two doses of a COVID-19 vaccine called BVX-0320 is effective in mouse models, a pre-clinical study has shown.
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Tweaking synonymous sites for gene therapy and vaccines
Professor Laurence D Hurst explains why understanding the nucleotide mutations in viruses, including SARS-CoV-2, can have significant implications for vaccine design.
