Drug Target Review – Issue #3 2015
21 September 2015 | By Drug Target Review
Included in this issue: Drug Development, Microfluidics, Proteomics, Ion Channels, GPCR, Imaging, Flow Cytometry, Enzymes
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Articles
Proteomics In-Depth Focus 2015
In this Proteomics In-Depth Focus: David J. Britton & Pedro R. Cutillas from Barts Cancer Institute ask should LC-MS/MS proteomics guide targeted drug selection for cancer patients? And Manfred Raida from the National University of Singapore explains how mass spectrometry and drug development come together...
Imaging In-Depth Focus 2015
In our Imaging In-Depth Focus: Dimitri Scholz and Jeremy C. Simpson from University College Dublin discuss trends in contemporary microscopy, Rudi Marquez and Zuzana Flachbartova share the bright future for molecular probes and Grischa Chandy from Molecular Devices LLC discusses changes and advantages with HCS microscopy...
When 0.77% is greater than 1%: salutatory lessons from the Court of Appeal
All new drugs rely, to a greater or lesser extent, on pre-existing research and development. Much of this pre-existing research will have resulted in patented methods and products. A major challenge for all researchers is therefore to develop new drugs which do not infringe other company’s patents.
Immunogenicity: anticipating and avoiding issues for biopharmaceutical development
All biopharmaceutical products are associated with an intrinsic potential to induce immune responses in treated subjects. Regulatory agencies expect sponsors to evaluate and mitigate these risks during product development, applying a strategy that addresses product- and patient-related factors. Overall, understanding and controlling immunogenicity-related risks are attainable objectives, and approvability should…
Microfluidic technology: the next-generation drug discovery tool
Microfluidic miniaturisation, or the so-called ‘lab-on-a-chip’ concept, now encroaches on the fields of biology, medicine and pharmacology, and the nature of microfluidic technology (small volumes and high-throughput integration of fluid connections) means that it is outperforming conventional bench work. There has been an incredible need for microfluidic technology in the…
Ion channels: Small molecules versus biologics – the quest for the ideal Nav1.7 inhibitor
Ion channels modulate and control many fundamental physiological processes in various tissues and alterations in their functions give rise to a wide range of pathophysiologies, which makes them important drug targets. Indeed, for decades, drugs modulating ion channel activity have been targeted by the pharmaceutical industry. Historically, however, developing drugs…
Exploiting functional selectivity of GPCRs in drug development
The large family of pharmaceutical targets represented by G-protein coupled receptors (GPCRs) are usually involved in a number of intracellular effector pathways, leading to many cellular outcomes. In recent years it has been uncovered that different ligands of a given GPCR may engage the pathways selectively, in that ligands that…
Flow cytometry: Not just a box in the lab
Undoubtedly, you will have noticed the increase in the number of publications utilising flow cytometry, heard it mentioned more in meetings and probably even been targeted by several companies trying to sell you their latest cytometer. The rapidly advancing technology behind the cytometer and an increase in applications that use…
SOMAscan™ assay: a vital proteomic tool in drug discovery
21 September 2015 | By SomaLogic
The SOMAscan™ assay is a highly multiplexed, sensitive, quantitative and reproducible proteomic tool for discovering biomarkers for drug discovery...
The importance of measuring drug target residence times
21 September 2015 | By BioTek
The Synergy Neo2 Multi-Mode Reader is designed to provide high temporal resolution in drug target kinetics applications...
Enzymes: Ubiquitin-specific proteases as druggable targets
In much the same way that kinases and phosphatases attach and remove phosphate groups from proteins to modulate their activity, there are a series of enzymes (E1, E2, E3) that add one or more ubiquitins onto a protein, as well as enzymes that remove them (deubiquitinases; DUBs), thereby regulating their…
SSPC – advancing science from molecule to medicine
6 August 2015 | By Synthesis and Solid State Pharmaceutical Centre (SSPC)
Read how the Synthesis and Solid State Pharmaceutical Centre (SSPC) is positioning Ireland as a global hub for advanced pharmaceutical manufacturing...
Stem cells: maintaining hope and challenging hype
6 July 2015 | By Caroline Richards, Editor
Inspired by her attendance at ISSCR 2015, Editor of Drug Target Review, Caroline Richards, discusses stem cells and the rise of unregulated stem cell practitioners...
Targeting cancer metabolism
Cancer cells are addicted to glucose and glutamine, which enables them to generate the energy and macromolecule synthesis intermediates to support their growth...
