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Spike protein analysis explains faster spread of SARS-CoV-2 variants
Using cryo-electron microscopy, researchers have imaged how the SARS-CoV-2 Spike protein changes with the D614G mutation to enable faster spread of infection.
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Study identifies potential drug target for treating COVID-19
Researchers have shown that the PLpro coronavirus enzyme presents a possible target in the fight against COVID-19.
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Researchers gain insight into metabolic pathways hijacked by SARS-CoV-2
SARS-CoV-2 diverts building blocks from glucose production to the assembly of purine bases, researchers have found.
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Antibodies from COVID-19 vaccines less effective against SARS-CoV-2 variants
Researchers have shown antibodies induced by the Pfizer and Moderna vaccines are less effective at neutralising certain SARS-CoV-2 variants.
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Mosquito protein could hold key to therapeutics against flaviviruses
A study has shown the mosquito protein AEG12 inhibits flaviviruses, the family of viruses that cause yellow fever, dengue and Zika.
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Antisense oligonucleotide with potential to combat COVID-19 developed
Scientists have designed a compound named ASO-1 that could help to reduce immune response overactivation in patients with COVID-19.
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What we know about COVID-19 and the inflammatory response
A year on from discovering COVID-19 we are starting to understand why some people suffer more severely after infection. Sadya Arnett discusses recent research into the interconnection between host inflammation and SARS-CoV-2.
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High-CBD cannabis extracts could provide COVID-19 treatment
Cannabidiol's (CBD) anti-inflammatory properties could be harnessed to treat or prevent COVID-19, according to a new study.
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SARS-CoV-2 mAb cocktail effective against all known variants of virus
A monoclonal antibody (mAb) cocktail, that targets sites on the Spike protein other than the E484K residue, can neutralise SARS-CoV-2.
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SARS-CoV-2 mutations complicate killer T cell immune response, study shows
Researchers have found that mutations in SARS-CoV-2 T cell epitopes enable the virus to evade the immune response of killer T cells.
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Compounds that inhibit main protease of SARS-CoV-2 discovered
Using high-throughput screening techniques, researchers have identified two families of active substances that block SARS-CoV-2 replication.
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Nanoparticle COVID-19 vaccine shows promise in pre-clinical trials
A new nanoparticle-based vaccine has demonstrated success in ferret models of COVID-19, inducing strong neutralising antibodies against SARS-CoV-2.
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In silico screening of existing drugs reveals three candidates against SARS-CoV-2
A novel in silico approach applied to drug screening has revealed three potential candidates that may interact with multiple proteins of SARS‐CoV‐2.
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Balanced T-cell response key to asymptomatic COVID-19, study suggests
A new study has suggested that asymptomatic individuals with COVID-19 mount an efficient T-cell response that protects the host.
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Screening by compound activity could accelerate drug discovery
Researchers have developed a new screening technique called biological activity-based modelling to identify drug candidates.
