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Procedural advances in IVF are reaching their biological limits. Reproductive biotech is now moving upstream, developing first in class therapeutics that target meiosis, gamete quality and implantation biology as druggable mechanisms in early discovery.
Scientists have restored sperm production in mice with a genetic form of male infertility using mRNA delivered via lipid nanoparticles, with the hope of informing future treatments for non-obstructive azoospermia.
Scientists have discovered the molecular ‘switch’ that powers sperm for fertilisation, which could potentially lead to new infertility treatments.
UCLA scientists have created the first detailed map of how the ovarian reserve forms in primates, offering new insights – and potential new treatments – for infertility, polycystic ovary syndrome (PCOS) and hormone-related conditions.
Kyoto University researchers have discovered a new DNA-organising protein complex called STAG3-cohesin – a protein that appears in human B cells and blood cancers. This discovery could potentially lead to new approaches for treating infertility and certain cancers.
New study reveals that TLE6 protein deficiency causes male infertility in mice. These findings suggest potential genetic causes and future treatment avenues for male infertility.
The publicly available Human Endometrial Cell Atlas could progress the development of therapeutics for endometriosis.
Epigenetic data assessing the effects of smoking on DNA methylation could serve as biomarkers of exposure effects.
In mouse models, the differences between oocytes collected by natural or stimulated approaches were investigated.
Single-cell RNA sequencing of ovaries resulted in the identification of four major cell types and four immune cell subtypes.
Scientists have reported a promising technique, based on somatic cell nuclear transfer, to treat infertility.
South Korean researchers have developed a hydrogel using a uterus-derived decellularised extracellular matrix, bringing hope for those challenged with infertility.
A study has identified that infertility due to age-related defects in eggs could be improved by raising levels of NAD, presenting a possible novel fertility treatment.
Scientists in the U.S. have published their findings about the behaviour of proteins in mouse eggs, projecting possible impacts on infertility and cancer treatment.
Researchers from the University of Chicago have uncovered the mechanism by which small RNA molecules (piRNAs) locate and silence foreign invading genes, whilst avoiding ‘self’ genes.
