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Parkinson's disease

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Scientists create a nanobody that could treat Parkinson’s disease

1 August 2022 | By Ria Kakkad (Drug Target Review)

Researchers have developed a nanobody that can penetrate the tough exterior of brain cells and untangle misshapen proteins that lead to Parkinson’s disease.

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NRG Therapeutics to develop small molecule disease-modifying medicines for debilitating chronic neurodegenerative disorders

24 June 2022 | By Ria Kakkad (Drug Target Review)

NRG is developing a pipeline of brain-penetrant small molecule inhibitors of the mitochondrial permeability transition pore (mPTP) with potential as first-in-class treatments for Parkinson's disease and motor neuron disease.

Senior Radiologist Controls MRI with Patient Undergoing Procedure.

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Ultra-powerful brain scanners offer hope for treating cognitive symptoms in Parkinson’s disease

31 May 2022 | By Nic Losardo (Drug Target Review)

Ultra-powerful 7T MRI scanners could be used to help identify those patients with Parkinson’s disease and similar conditions most likely to benefit from new treatments for previously untreatable symptoms.

Close Up Of Senior person Suffering With Parkinsons Diesease

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Stem cell replacement therapy: a potential treatment for Parkinson’s disease

13 May 2022 | By Ria Kakkad (Drug Target Review)

In a new study, researchers describe a process for converting non-neuronal cells into functioning neurons able to restore capacities undermined by Parkinson’s destruction of dopaminergic cells.

Closeup view of a MRI head scan with brain

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Brain organoids may boost drug screening for neurological disorders

2 May 2022 | By Ria Kakkad (Drug Target Review)

Neuroscientists have designed brain organoids to contain both mature neurons and astrocytic glial cells in relative proportions like the human brain.

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New research points to a possible driver of Parkinson’s disease

28 February 2022 | By Ria Kakkad (Drug Target Review)

A study has shown how Parkinson’s disease may be driven by cell stress-related biochemical events that disrupt a key cellular clean-up system.

3D illustration showing neurons containing Lewy bodies small red spheres which are deposits of proteins accumulated in brain cells that cause their progressive degeneration

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Possible improvement to Parkinson’s disease treatment shown in study

25 February 2022 | By Ria Kakkad (Drug Target Review)

Research from the University of Copenhagen reveals how Deep Brain Stimulation treatment of walking problems in Parkinson’s disease could be optimised by targeting specific neurons in the brainstem.

article

CRISPR activation screening: finding genes that interact with SARS-CoV-2

17 January 2022 | By Dr Greg Neely (University of Sydney)

Dr Greg Neely, University of Sydney, explains how he and his team used pooled whole genome CRISPR activation screening to identify LRRC15 as a SARS-CoV-2 spike-interacting protein.

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Virtual method enables screening of billions of chemical compounds

10 January 2022 | By Victoria Rees (Drug Target Review)

A new platform, named Virtual Synthon Hierarchical Enumeration Screening, has been developed by researchers to efficiently discover drugs.

article

Analysing proteomics data to translate in vivo studies as early as possible

13 December 2021 | By Dr Antal Szalay (Ultimate Medicine)

Dr Antal Szalay, CEO and Founder of Ultimate Medicine, explores how the analysis of omics data, especially metabolomics and proteomics, can provide researchers with vital insight that can inform the development of drugs for conditions associated with age.

article

Highlights from Drug Target Review’s Cell & Gene Therapy Advancements Online Summit

13 December 2021 | By Drug Target Review

Here, we round up some of the key takeaways from the expert panel discussions at the Cell & Gene Therapy Advancements Online Summit.

news

New Oxford-GSK Institute aims to unravel complex diseases

2 December 2021 | By Anna Begley (Drug Target Review)

GlaxoSmithKline (GSK) and the University of Oxford will collaborate to investigate diseases using technologies such as functional genomics and machine learning.

Hand of person with Parkinson's shaking while holding glass of water

news

New compound may reduce erratic movements in Parkinson’s patients

2 December 2021 | By Anna Begley (Drug Target Review)

Scientists identify a drug candidate to minimise erratic muscle movements, called dyskinesia, associated with Parkinson’s disease.

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Alterity’s ATH434 improves Parkinson’s-related gastrointestinal dysfunction

4 November 2021 | By Anna Begley (Drug Target Review)

ATH434 reversed some of the gastrointestinal damage to the enteric nervous system associated with Parkinson's disease in a pre-clinical study.

news

Gene therapy bolsters Parkinson’s drug benefits in pre-clinical study

3 November 2021 | By Anna Begley (Drug Target Review)

The gene therapy restored the ability of neurons to convert levodopa to dopamine and may help develop therapies to slow disease progression.

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Parkinson's disease