New T-cell discovery could lead to treatments for both bacterial infections and autoimmune conditions
A novel highly activated form of T cells could be suppressed to treat autoimmune conditions and activated in treating bacterial infections.
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Boosting natural killer cells in mice with eczema relieves condition
Researchers have found that using IL-15 to boost natural killer cell numbers in mice helps to combat eczema and could be a therapeutic strategy for patients.
Infrared light used to improve photodynamic therapy in model tumours
Researchers have developed a compound that can be activated with infrared light to kill cancer cells in model tumours, advancing the possibilities of photodynamic therapy.
Antibacterial cannabinoid compound identified by researchers
A study has revealed that the compound cannabigerol (CBG) is effective as an antibacterial in mice, by preventing bacteria from forming biofilms.
Possible novel cognitive anti-ageing targets identified
Researchers have shown that two epigenetic regulators could be targeted to improve cognitive and behavioural decline in age-related diseases like Alzheimer’s.
New study helps improve the understanding of bacteria and viruses
A new study has revealed how bacterial immune systems can be harmful for their hosts and why they are not found in all bacteria.
Coronavirus update: recent developments in vaccine research
Drug Target Review’s round-up of the latest developments in 2019 novel coronavirus (COVID-19 or SARS-CoV-2) therapeutics and vaccines.
Chemical reactions database updates to improve R&D information exchange
The newest version of the Unified Data Model (UDM) project has been released, allowing R&D scientists to access information on compound synthesis and testing.
Natural killer cells identified as source of inflammation in rheumatoid arthritis
A study has shown that natural killer cells are linked to the protein GM-CSF, which causes inflammation, indicating a new target for rheumatoid arthritis.
Lung cells found to support hibernating breast cancer cells in mice, revealing target
A study has shown that breast cancer cells are protected by healthy cells in the lungs of mice, allowing them to hibernate before growing into tumours.
Non-coding RNA may interact with chromatin to control gene expression
The development of an innovative new technology has led researchers to suggest RNA-chromatin interactions may play a role in gene regulation.
Depletion and repopulation of microglia could be a future therapy for TBI
Researchers have shown that by effectively resetting the microglia, recovery of mice after a traumatic brain injury (TBI) was improved.
Researchers generate atlas of thymus to understand T-cell development
A new study has created an atlas of human thymus development, to reveal which genes are needed for the production of specific T cells.
Compound combination successful against Pseudomonas aeruginosa
Researchers have developed a new combination of compounds called AB569 which has demonstrated success at fighting deadly pathgoens like Pseudomonas aeruginosa.
RCAN1 gene revealed as regulator of Down syndrome symptom
A study has shown that the RCAN1 gene plays a role in regulating synaptic plasticity, which contributes to a sympom of Down syndrome.
