NLRP3 inflammasome ‘off switch’ reverses effects of chronic inflammation
Research into age-related chronic inflammatory disorders has identified an ‘off switch’ on the NLRP3 inflammasome that could be targeted in new therapies.
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Retinoid X receptor could be targeted to improve recovery from stroke
Scientists conducted a pre-clinical trial in mice and showed that activating the retinoid X receptor (RXR) enhances the activity of phagocytic immune cells and aids recovery from stroke.
Immune system regulator shifts immune cell balance
Researchers have provided new insight into the role of cyclic AMP (cAMP) in regulating the immune response which may lead to new ways of treating diseases.
Report finds £4.8m of funding contributed to UK health research in 2018
Researchers have found that half of public and charity support for health research over the past 14 years has been for studying the cause and progression of disease.
Blocking IL-17 could provide new multiple sclerosis treatment strategy
Researchers have revealed that inhibiting IL-17 could prevent the effects of autoimmune diseases, including multiple sclerosis.
Oligodendrocyte abnormality identified as potential cause of autism
Researchers have revealed that the disruption of oligodendrocytes, which produce myelin, may be a cause of autism spectrum disorder, so presents a therapeutic target.
Interaction site for serotonin type 3A and RIC-3 chaperone identified
To address the receptor dysfunction associated with several neurological diseases, scientists have provided novel insights into a protein-protein interaction that could lead to more effective treatments.
Kidney stem cells isolated from urine could be the future of regenerative therapies
Research into alternative stem cell sources has identified urine derived renal progenitor cells (UdRPCs) as a possible option for use in regenerative kidney therapies in the future.
C1 compound identified as promising Alzheimer’s drug candidate
Researchers have screened thousands of drugs to discover that C1 effectively blocks the production of amyloid fibrils, so could be an effective therapeutic.
Method to make integrin receptor-targeting drugs safer in future presented in study
Research into the structure of the drug-integrin complex has enabled the creation of drugs which inhibit integrin as effectively as currently used compounds, without causing excessive bleeding.
Influenza B M2 proton channel structure resolved by researchers
Research into the M2 proton channel of influenza B has revealed its structure, which the team hope can aid in the development of targeted therapeutics to block the channel and treat the condition.
Researchers highlight link between microbiome and melanoma
A study of published papers has revealed the importance of research into how the microbiome affects the development of melanoma.
D6PV peptide lowers triglycerides in mouse bloodstream, shows study
Researchers have used a peptide called D6PV to lower triglycerides in mouse models, which could be used as a therapy for high triglyceride-induced acute pancreatitis in humans.
RNA methylation knock-out mutant could be potential HMPV vaccine
Research has shown that human metapneumovirus uses RNA methylation to hide from the immune system and that knocking out this methylation creates a mutant strain which acts like a vaccine.
Molecule of blood found to be effective against lupus
Scientists have found that a molecule present in our blood, called C4BP (β-), could be used in a therapeutic capacity for lupus as well as potentially other autoimmune disorders.
