Promising new RNA editing technology could be used to treat genetic diseases
New research by the University of California, San Diego could provide a much simpler way to repair disease-causing mutations in RNA.
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Engineered airway lining created to study how COVID-19 affects respiratory tracts
Researchers have made a respiratory model of COVID-19, made from patient-derived stem cells, to understand how the virus affects respiration and which could be used to test possible drugs.
Novel antibody could reduce SARS-CoV-2 transmission
Researchers at UC Davis Health have engineered an antibody that interferes with a critical cell mechanism to reduce transmission of the virus that causes COVID-19 in lab tests.
Promising target for osteoporosis treatments found in new study
By identifying a mechanism behind bone strengthening in response to stress, researchers have found a possible new target for treating conditions that weaken bones.
Study identifies new therapeutic target for haematologic malignancies
Using chemical genetic screening and pre-clinical model studies, researchers have discovered that inducing ubiquitin-mediated degradation of mutant EZH2 could provide a more effective treatment strategy for haematologic malignancies.
Five SARS-CoV-2 antiviral candidates revealed in drug screening study
Using virtual screening, researchers have discovered several natural compounds that could inhibit the SARS-CoV-2 main protease.
Pathway to treat type 1 diabetes revealed in study
A new study has identified harmful cellular pathways that prevent insulin production, presenting a drug target for diabetes.
Tweaked bacteria genes activate heart cells in mice
Researchers have shown that engineered bacterial genes coding for sodium ion channels could lead to novel gene therapies for electrical heart diseases.
Novel CAR T-cell therapy for B-cell cancers shows promise in vivo
A new CAR T-cell therapy for B-cell cancers promises to reduce the antigen escape currently found in therapies that only target CD19.
New research sheds light on what influences target protein binding time
The length of time that drug molecules attach to their target protein varies greatly and impacts the protein’s behaviour and drug efficacy. In a new study, scientists in Finland have identified some causal factors for this variance, with the hope it will bring clarity for drug developers.
Multifaceted flu vaccine demonstrates wider protection
Scientists at Georgia State University have developed an intranasal influenza vaccine using a new combination of nanoparticles for improved defence against flu strains.
Researchers identify potential drugs to reduce COVID-19 mortalities
Researchers have established a list of compounds that effect cytokine storms that could reduce mortality in COVID-19 patients.
Model to study oculocutaneous albinism eye conditions developed
The first patient-derived stem cell model to research eye conditions related to oculocutaneous albinism (OCA) has been created.
New model yields promising gene therapy for heart condition
Scientists in Japan have developed a credible heart cell model for arrhythmogenic cardiomyopathy and observed a positive response in the condition using PKP2 gene therapy.
New protein that enables SARS-CoV-2 access into cells identified
Researchers have found that extracellular vimentin facilitates SARS-CoV-2 entry into human cells, presenting a new target.
