List view / Grid view

Therapeutics

article

SARS-CoV-2 and immunology: antibody developments

15 February 2021 | By Victoria Rees (Drug Target Review)

Discover the latest in SARS-CoV-2 antibody research as we cover three of the most recent developments in this article.

news

EIDD-2801 proven to prevent SARS-CoV-2 infection in vivo

10 February 2021 | By Victoria Rees (Drug Target Review)

The drug EIDD-2801 was shown to prevent SARS-CoV-2 replication and infection of cells in a new mouse model containing human lung tissue.

news

Thapsigargin could be used as antiviral to treat COVID-19, study shows

3 February 2021 | By Victoria Rees (Drug Target Review)

Researchers have discovered that thapsigargin has novel antiviral properties and is effective against COVID-19 in pre-clinical studies.

Computer screen displaying DNA strand, human body and organs and various tablets - idea of technology for medicine screening

news

Novel AI tool takes a DeepCE dive into potential drugs for COVID-19

2 February 2021 | By Hannah Balfour (Drug Target Review)

A new phenotype-based compound screening technology, called DeepCE, identified 10 compounds that could be repurposed for COVID-19.

news

Novel protein could neutralise SARS-CoV-2 infection in kidneys

2 February 2021 | By Victoria Rees (Drug Target Review)

A new protein can trick SARS-CoV-2 and bind to the Spike protein rather than cell membranes in a kidney organoid.

Coronavirus particles in green with purple extracellular proteins

news

N439K variant of SARS-CoV-2 is resistant to some neutralising antibodies, shows study

1 February 2021 | By Hannah Balfour (Drug Target Review)

The N439K mutation improves the interaction between SARS-CoV-2 Spike protein and the viral receptor ACE2 and eludes antibody-mediated immunity, say investigators.

SARS-CoV-2 spike protein bound to an ACE2 receptor on the cell surface

news

Heparin inhibits SARS-CoV-2 invasion, finds study

29 January 2021 | By Hannah Balfour (Drug Target Review)

Research suggests heparin could be repurposed for COVID-19 because it can bind to the SARS-CoV-2 Spike protein and prevent the virus from infecting cells in vitro.

news

Melatonin could act as barrier against SARS-CoV-2 infection

28 January 2021 | By Victoria Rees (Drug Target Review)

Researchers have suggested using melatonin in a nasal spray to create a protective barrier against SARS-CoV-2 in pre-symptomatic patients.

white antibodies attacking an orange coronavirus particle with yellow neuraminidase proteins on its surface

news

Novel antibody candidate could offer pan-coronavirus protection

26 January 2021 | By Hannah Balfour (Drug Target Review)

The lead candidate, ADG2, was able to neutralise SARS-CoV and various strains of SARS-CoV-2, including those that are resistant to currently available antibody treatments.

Blue and white caspsules - potentially NSAIDs - on a yellow background

news

NSAIDs could be damaging to COVID-19 patients, dependent on timing, suggests study

25 January 2021 | By Hannah Balfour (Drug Target Review)

In murine models of COVID-19, researchers found that non-steroidal anti-inflammatory drugs (NSAIDs) can suppress the inflammatory response and production of antibodies.

news

Novel nanobody combinations protect cells from SARS-CoV-2 in vitro

14 January 2021 | By Hannah Balfour (Drug Target Review)

By combining nanobodies targeting different regions of the SARS-CoV-2 Spike protein, researchers were able to protect cells from infection.

yellow SARS-CoV-2 particles in a black alveoli

news

Novel human alveolar tissue model could help COVID-19 drug development

12 January 2021 | By Hannah Balfour (Drug Target Review)

Researchers will use the in vitro model to study how respiratory viruses, like SARS-CoV-2, cause Acute Respiratory Distress Syndrome (ARDS) and develop potential interventions.

news

Drug screening reveals pralatrexate could be repurposed to treat COVID-19

4 January 2021 | By Victoria Rees (Drug Target Review)

Computational drug screening has shown that chemotherapy drug pralatrexate could potentially be repurposed to treat COVID-19.

SARS-CoV-2 particle surrounded by red blood cells in a blood vessel - idea of COVID-19 causing blood clots

news

Opaganib shows promise in preventing ARDS-induced thrombosis

16 December 2020 | By Hannah Balfour (Drug Target Review)

Opaganib reduced blood clot length and weight in a pre-clinical model of Acute Respiratory Distress Syndrome (ARDS).

red coronavirus particles next to blue DNA strands

news

Genome-wide association study reveals targets for COVID-19 treatments

14 December 2020 | By Hannah Balfour (Drug Target Review)

The study found five key genetic differences when they compared sequences from severe COVID-19 patients to healthy individuals.

Cookie	Type	Duration	Description
cookielawinfo-checkbox-advertising-targeting	persistent	1 year	The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Advertising & Targeting".
cookielawinfo-checkbox-analytics	persistent	1 year	This cookie is set by GDPR Cookie Consent WordPress Plugin. The cookie is used to remember the user consent for the cookies under the category "Analytics".
cookielawinfo-checkbox-necessary	persistent	1 year	This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Necessary".
cookielawinfo-checkbox-performance	persistent	1 year	This cookie is set by GDPR Cookie Consent WordPress Plugin. The cookie is used to remember the user consent for the cookies under the category "Performance".
PHPSESSID	session	1 year	This cookie is native to PHP applications. The cookie is used to store and identify a users' unique session ID for the purpose of managing user session on the website. The cookie is a session cookies and is deleted when all the browser windows are closed.
viewed_cookie_policy	persistent	1 year	The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. It does not store any personal data.
zmember_logged	session	1 year	This session cookie is served by our membership/subscription system and controls whether you are able to see content which is only available to logged in users.

Cookie	Type	Duration	Description
advanced_ads_browser_width	persistent	1 month	This cookie is set by Advanced Ads and measures the browser width.
advanced_ads_page_impressions	persistent	2 years	This cookie is set by Advanced Ads and measures the number of previous page impressions.
advanced_ads_pro_server_info	persistent	1 month	This cookie is set by Advanced Ads and sets geo-location, user role and user capabilities. It is used by cache busting in Advanced Ads Pro when the appropriate visitor conditions are used.
advanced_ads_pro_visitor_referrer	persistent	1 year	This cookie is set by Advanced Ads and sets the referrer URL.
bscookie	persistent	2 years	This cookie is a browser ID cookie set by LinkedIn share Buttons and ad tags.
IDE	persistent	2 years	This cookie is set by Google DoubleClick and stores information about how the user uses the website and any other advertisement before visiting the website. This is used to present users with ads that are relevant to them according to the user profile.
li_sugr	persistent	3 months	This cookie is set by LinkedIn and is used for tracking.
UserMatchHistory	persistent	1 month	This cookie is set by Linkedin and is used to track visitors on multiple websites, in order to present relevant advertisement based on the visitor's preferences.
VISITOR_INFO1_LIVE	persistent	5 months	This cookie is set by YouTube. Used to track the information of the embedded YouTube videos on a website.

Cookie	Type	Duration	Description
bcookie	persistent	2 years	This cookie is set by LinkedIn. The purpose of the cookie is to enable LinkedIn functionalities on the page.
GPS	persistent	30 minutes	This cookie is set by YouTube and registers a unique ID for tracking users based on their geographical location
lang	session	1 year	This cookie is set by LinkedIn and is used to store the language preferences of a user to serve up content in that stored language the next time user visit the website.
lidc	persistent	1 day	This cookie is set by LinkedIn and used for routing.
lissc	persistent	11 months	This cookie is set by LinkedIn share Buttons and ad tags.
vuid	persistent	2 years	We embed videos from our official Vimeo channel. When you press play, Vimeo will drop third party cookies to enable the video to play and to see how long a viewer has watched the video. This cookie does not track individuals.
wow.anonymousId	persistent	2 years	This cookie is set by Spotler and tracks an anonymous visitor ID.
wow.schedule	persistent	20 minutes	This cookie is set by Spotler and enables it to track the Load Balance Session Queue.
wow.session	persistent	20 minutes	This cookie is set by Spotler to track the Internet Information Services (IIS) session state.
wow.utmvalues	persistent	20 minutes	This cookie is set by Spotler and stores the UTM values for the session. UTM values are specific text strings that are appended to URLs that allow Communigator to track the URLs and the UTM values when they get clicked on.
_ga	persistent	2 years	This cookie is set by Google Analytics and is used to calculate visitor, session, campaign data and keep track of site usage for the site's analytics report. It stores information anonymously and assign a randomly generated number to identify unique visitors.
_gat	persistent	1 minute	This cookies is set by Google Universal Analytics to throttle the request rate to limit the collection of data on high traffic sites.
_gid	persistent	1 day	This cookie is set by Google Analytics and is used to store information of how visitors use a website and helps in creating an analytics report of how the website is doing. The data collected including the number visitors, the source where they have come from, and the pages visited in an anonymous form.

Cookie	Type	Duration	Description
cf_ob_info	persistent	1 minute	This cookie is set by Cloudflare content delivery network and, in conjunction with the cookie 'cf_use_ob', is used to determine whether it should continue serving “Always Online” until the cookie expires.
cf_use_ob	persistent	1 minute	This cookie is set by Cloudflare content delivery network and is used to determine whether it should continue serving “Always Online” until the cookie expires.
free_subscription_only	session	1 year	This session cookie is served by our membership/subscription system and controls which types of content you are able to access.
ls_smartpush	persistent	1 month	This cookie is set by Litespeed Server and allows the server to store settings to help improve performance of the site.
one_signal_sdk_db	persistent	Until cleared	This cookie is set by OneSignal push notifications and is used for storing user preferences in connection with their notification permission status.
YSC	session	1 year	This cookie is set by Youtube and is used to track the views of embedded videos.

Recommended

Therapeutics