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Application note: Evaluation of hepatic function in 3D culture
In vitro evaluation of hepatic function using a primary human hepatocyte 3D spheroid culture system
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Assays
An assay is an analytical procedure in laboratory medicine, pharmacology and molecular biology for measuring the activity of a target entity.
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Application note: Hypoxia measurements in live and fixed cells
Hypoxia measurements in live and fixed cells using fluorescence microscopy and high-content imaging
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ebook: The ELISA Guide – to your successful experiments
Enzyme Linked Immunosorbent Assays (ELISAs) are one of the most common immunoassays on the market.
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Exploring chemical space for epigenetic drug discovery using AI
It is said that, on average, it takes a new drug 12 years to go from research lab to patient, with many thousands of candidates discarded along the way. Can artificial intelligence (AI) help to speed things up? Sheraz Gul and Alp Sahin provide an overview of an AI approach…
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Assay for reading six molecular pathways simultaneously developed
Researchers have developed a luciferase assay that can be used to monitor the effects of treatments on six different molecular targets at once.
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Application note: CAR T Cell Research
Chimeric antigen receptor (CAR) T cell transfer has had success as a treatment for leukemia and lymphoma, but solid tumors have been more challenging due to the rarity of true tumor-specific target molecules and the immunosuppressive nature of the tumor microenvironment.
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Expert view – The Octet HTX system: enabling multi-purpose screening of therapeutic biologics during development
Current trends in the development of therapeutic biologics suggest that engineered molecules such as bispecific antibodies and antibody-drug conjugates are the future of the industry, yet despite this, monoclonal antibody (mAb) development remains a dominant focus.
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Expert view: Promising methods in kinase screening
Kinase-mediated phosphorylation is a control point for nearly all activity within a cell, making kinases important in many diseases.
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Expert view: Following mitchondrial substrate oxidation pathways to expose novel drug targets
Energy metabolism drives everything we do, so it is no surprise that the more we discover about these metabolic processes, the more we observe seamless integration with all core cellular functions.
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Drug Target Review – Issue 4 2019
This issue includes a discussion on the future of high-throughput screening through collaboration, an analysis of mass spectrometry as a structural biology tool and an exploration of the challenges of hit-to-lead when researching tropical diseases. Also in the issue are articles on immuno-oncology and assays.
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Application note: Measure cancer cell viability using a homogeneous, stable luminescence assay
Learn how to screen for cell viability with the CellTiter-Glo assay on the SpectraMax® iD5 Multi-Mode Microplate Reader.
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eBook: Streamline beer, wine, and food quality control and safety analyses
Using absorbance microplate readers to streamline beer, wine and food safety analyses using industry-standard approved methods.
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Application note: Detect endotoxin with the PyroGene Recombinant Factor C Assay
Get increased sensitivity for the detection of endotoxin in a fluorescence assay.
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Application note: A Simoa™ Bridging Assay for Anti Drug Antibody Detection
Therapeutic drugs based on biological materials (antibodies, hormones, cytokines, enzymes, fusion proteins) may have the ability to elicit an immune response in the host.
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Application note: A Simoa ™ Pharmacokinetic Bridging Assay
Pharmacokinetics (PK) refers to the movement of a drug through the body. The distribution, absorption, metabolism, and excretion of a drug are all important pharmacokinetic factors to be considered in the development of therapeutics.
