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The growing possibilities for stem cells in pharma
Drug Target Review explores the latest applications of stem cells in modelling disease, drug production and the most recent steps in regenerative medicine provided by research.
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Cell Regeneration
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Combination therapy of α -KLOTHO and TGFβR2 improves osteoarthritis
A study has shown that a combination of α-KLOTHO and TGF β receptor 2 (TGFβR2) recovers cartilage in rats with osteoarthritis and could be a new therapy for humans.
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Levels of neurogenesis could be a therapeutic target in neurodegenerative disease
Research has identified that regions of the brain can regenerate via neural stem cells and the process of neurogenesis which could provide a new avenue for regenerative therapeutics.
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MLL gene key to producing hematopoietic stem cells, says research
Researchers investigating childhood leukaemia have discovered that increasing MLL gene expression in iPSCs drives hematopoietic stem cell production, so could be the target of new therapies.
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Novel form of cell-free therapy revealed by researchers
Researchers have developed cytochalasin B-induced membrane vesicles which they suggest could be a new form of cell-free therapy in regenerative medicine.
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Histones revealed by study as critical for cell identity
Researchers have shown that histones are vital in silencing genes and that their position is inherited in new cells, providing insight into how cancer cells can become resistant to therapy.
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Human stem cell combination could help damaged hearts live longer
A combination of heart cells derived from human stem cells could lead to developing a treatment for heart failure.
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New approach shows regeneration of severely damaged lungs
Researchers are first to demonstrate in a clinically relevant model that damaged lungs can be regenerated to meet transplantation criteria.
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Scientists restore functions in pig’s brain hours after death
Scientists have reported circulation and cellular activity being restored in a pig's brain four hours after its death, challenging long-held assumptions about the timing and irreversible nature of the cessation of some brain functions after death.
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Nuclear tracers help assess new drugs for neurodegenerative diseases
New nuclear medicine tracers could help medical researchers find a cure for Alzheimer's and other neurodegenerative diseases.
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Application note: GABAA Receptors
SB Drug Discovery shows the validation of fluorescence and automated electrophysiology assays designed to assess agonists, antagonists and allosteric modulators of these receptors, culminating in a high-throughput electrophysiology assay suited to assessing multiple GABAA receptor subtypes on a single assay plate.
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Compounds in coffee may fight Parkinson’s
Caffeine plus another compound in coffee beans' waxy coating may protect against brain degeneration...
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Stimulating fibroblasts can trigger hair growth in wound healing
Stimulating fibroblasts through the sonic hedgehog pathway can trigger hair growth not previously seen in wound healing...
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MRI scans shows promise in predicting dementia
Brain changes evident in scans before memory, cognitive decline...
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Powerful molecules provide new findings about Huntington’s disease
Researchers have discovered a direct link between the protein aggregation in nerve cells that is typical for neurodegenerative diseases, and the regulation of gene expression in Huntington's disease...
