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Enzyme involved in cancer growth imaged for first time
A study has revealed the structure of an enzyme that promotes cancer growth by mutating RNA, which could be used in the development of cancer treatments.
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Enzymes
Enzymes are macromolecular biological catalysts. Enzymes accelerate, or catalyse, chemical reactions.
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Potential antibiotic alternative discovered within bacteria
A study has revealed an enzyme in bacteria that produces a molecule which is toxic to other bacteria and shows promise as an antibiotic substitute.
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Kinase identified as potential target for heart failure treatment
A new study has shown that restoring the amount of the kinase, HIPK2, in a kinase-depleted mouse model rescued it from heart failure and identifies HIPK2 as a novel regulator of heart failure progression.
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Collaborative enzyme study could lead to a target for cancer therapeutics
A new study into the enzyme Cdc34 may make it possible to target the enzyme specifically to develop new cancer therapeutics.
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Selective inhibitor could reduce resistance to cancer therapies
A study has found a selective inhibitor for an enzyme that allows cancer cells to mutate and become resistant to treatments.
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Three-dimensional structure of the genome replication machine discovered
New research provides insights into how cancers can arise when DNA polymerase delta is not functioning properly.
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Researchers reveal how fungi produce potential therapeutic compounds
A team has discovered that fungi use the Diels-Alder reaction to assemble new compounds that have potential pharmaceutical uses.
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Inflammatory regulator molecule identified by study
Researchers have discovered an enzyme that is pivotal in deciding whether cells survive or die in inflammatory diseases, so provides a drug target.
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Compound promotes healing of myelin in nervous system disorders
A compound that promotes the rebuilding of the protective sheath around nerve cells damaged in multiple sclerosis has been developed.
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Structure of crucial metabolic enzyme revealed by high-end microscopy
Scientists reveal the atomic structure and regulative mechanism of the metabolic enzyme transhydrogenase.
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Possible treatment discovered for severe dengue disease
New findings suggest a possible new treatment strategy for severe dengue disease using the tryptase inhibitor, nafamostat mesylate.
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Gene linked to rare disorder also regulates key enzyme in Alzheimer’s
A gene associated with a rare balance disorder also regulates the behaviour of an enzyme that increases the risk for Alzheimer's disease.
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Osteoporosis in mice reversed with new drug target
A pharmaceutical target has been identified by Duke University that, when activated, can reverse bone degradation caused by osteoporosis.
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Key mechanism in tuberculosis survival discovered
A new study has revealed that M. tuberculosis uses a unique type of antacid which gives immune cells indigestion, enabling the bacteria to survive.
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Single enzyme provides target for new sepsis drugs
Researchers have discovered that removing the enzyme, PHLPP1, improves outcomes in a mouse model of sepsis so could be a potential drug target.
