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Immuno-oncology

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Club cell factors may reverse immune suppression in tumours

21 September 2021 | By Anna Begley (Drug Target Review)

New research has revealed that club cells secret anti-immunosuppressive factors in tumours, potentially revolutionising cancer therapies.

news

Controlling PTEN gene could combat paediatric rhabdomyosarcoma

20 September 2021 | By Anna Begley (Drug Target Review)

The decreased expression of PTEN in mouse models was found to make rhabdomyosarcoma tumours more aggressive, highlighting new treatment approaches.

whitepaper

Cell & Gene Therapy Advancements Whitepaper

16 September 2021 | By Drug Target Review

Download this whitepaper to discover the latest research and developments in cell and gene therapies via exclusive articles and interviews.

news

Novel tool can estimate number of T cells in cancer tumours

10 September 2021 | By Anna Begley (Drug Target Review)

Researchers have developed a new method that can rapidly count the number of T cells in a tumour, helping to predict patient response to therapies.

news

STING-activating drugs could customise cancer treatments

9 September 2021 | By Anna Begley (Drug Target Review)

An imaging technique identified emerging drugs that activate the STING protein to alter metabolic pathway activity in cancer cells.

news

Stem-like T cells could improve immunotherapy treatments

7 September 2021 | By Anna Begley (Drug Target Review)

Targeting stem-like T cells within certain lymph nodes could improve the number of cancer patients that respond to immunotherapy treatments.

news

RN7SL1 RNA shown to activate T cells to fight against cancer

6 September 2021 | By Anna Begley (Drug Target Review)

A new study found that the RNA RN7SL1 can activate T cells to seek out cancer cells, potentially improving cellular treatments.

video

Drug Target Review update: exclusive report, online summit and more!

25 August 2021 | By Drug Target Review

Hear about the latest Drug Target Review updates from Deputy Editor Victoria Rees who discusses our new report on AI & Informatics, the Cell & Gene Therapy Advancements online summit and much more!

news

High-intensity focused ultrasound therapy moves closer to the clinic

24 August 2021 | By Anna Begley (Drug Target Review)

Researchers are investigating how high-intensity focused ultrasound (HIFU) can work on a cellular level to treat a range of cancers.

White blood cells as part of immune response to leukaemia

news

Existing drug may improve immune response to leukaemia treatment

18 August 2021 | By Anna Begley (Drug Target Review)

Researchers identified the inhibitor JQ1 as a potential drug to improve immune response to CAR T-cell therapies in leukaemia patients.

news

Enzyme discovery could fight against cancer and viral infections

17 August 2021 | By Anna Begley (Drug Target Review)

A new study has identified a vital enzyme, known as APOBEC3A, that could lead to new treatments against cancers and viral infections.

news

New nanotechnology could combat colorectal cancer and melanoma

16 August 2021 | By Anna Begley (Drug Target Review)

A nanotherapeutic delivery system displayed high efficacy against metastatic tumours in mice, potentially improving chemotherapy treatments.

news

Triple drug combination shows promise for pancreatic cancer treatment

10 August 2021 | By Anna Begley (Drug Target Review)

MIT researchers have shown that a combination of three drugs can eliminate pancreatic tumours in mice, possibly leading to new therapies.

news

Therapeutic target for aggressive cancers discovered through CRISPR

5 August 2021 | By Anna Begley (Drug Target Review)

The RNA-modifying protein METTL1 could be targeted to treat some types of aggressive cancers, including brain, blood and kidney.

news

Removal of RNA-binding protein improves leukaemia survival

30 July 2021 | By Anna Begley (Drug Target Review)

Study shows that removing the protein IGF2BP3 slows cancer growth and increases chances of survival of rare types of leukaemia in mice.

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Immuno-oncology