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Hepatitis C drugs could combat SARS-CoV-2, researchers find
Researchers have identified hepatitis C drugs that can inhibit the SARS-CoV-2 main protease, which enables the coronavirus to reproduce.
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In Vitro
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Novel technique reveals Parkinson’s changes how neurons sense oxygen
The new approach enables researchers to isolate brain cells associated with Parkinson's disease and study their gene expression patterns.
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LMTK3 inhibitors could be an effective breast cancer therapy, say scientists
Researchers demonstrate that inhibiting the LMTK3 kinase is an effective anticancer strategy in murine models of breast cancer.
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Developing nanobodies and sybodies to combat COVID-19
Three separate studies have identified nanobodies – a miniature form of antibodies found in camelid species – that can bind to the SARS-CoV-2 Spike (S) protein and neutralise the virus in cells.
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Cell line development services market to grow at 13.3 percent
Reports suggest the market growth is driven by advances in biotechnology and its applications, as well as COVID-19 research.
![robotic hand pipetting from petri dish of organoids next to a clock - idea of automation speeding up organoid development [Credit: Daria Sokol/MIPT Press Office].](https://www.drugtargetreview.com/wp-content/uploads/algorithm-accelerating-organoid-development.jpg)
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Researchers accelerate organoid development and selection using algorithm
The semi-automated process enabled researchers to make retinal organoid production and selection nearly four times faster.
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Researchers develop ACE2 decoy to neutralise SARS-CoV-2
Using their de novo protein design strategy, researchers engineered human angiotensin converting enzyme 2 (hACE2) protein decoys that can protect cells from SARS-CoV-2 infection.
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Developing drugs for disordered proteins
Scientists have developed a drug-like molecule to target amyloid-beta, a disordered protein implicated in Alzheimer's disease that has been considered undruggable.
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Researchers reveal how allergens may trigger itching
Certain sensory neurons and Substance P are potential drug targets for the development of novel allergy preventions or treatments, according to scientists.
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Lysosomes key to coronavirus shedding, finds study
Scientists reveal that coronaviruses de-activate lysosomes before using them to exit infected cells and spread through the body.
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Organs-on-a-chip model for breast cancer drug cardiac toxicity testing
The newly developed chip includes heart and breast cancer tissues and could be used to predict the cardiac toxicity of chemotherapeutic drugs.
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SARS-CoV-2 also uses neuropilin-1 to infect human cells
Researchers reveal that SARS-CoV-2 is more infectious than SARS-CoV because it can use both ACE2 and neuropilin-1 to infect cells.
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Researchers uncover drivers of memory B cell formation
The team demonstrated that expression of Bach2 protein and reduced mTORC1 activity is necessary for germinal B cells to become memory B cells.
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CRISPR used to eliminate cancers caused by fusion genes
Using CRISPR to cut out fusion genes, scientists were able to specifically induce cancer cell death in murine models of sarcoma and leukaemia.
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Small molecules to reduce cellular stress identified by HTS
Scientists used high throughput screening (HTS) to identify molecules that protect against cellular stress in murine skin cells.
