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Nanodecoy therapy neutralises SARS-CoV-2 in macaques
Lung spheroid cells can act as nanodecoys for the SARS-CoV-2 Spike protein to bind to, according to a new pre-clinical study.
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In Vivo
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Stem cells may be key for new vaccines against COVID-19
Scientists say COVID-19 may activate tuberculosis infection, but stem cell-mediated defence mechanisms could be targeted to develop vaccines.
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Study provides clues to cause and possible treatment of Parkinson’s
Researchers have shown that the leakage of mitochondrial double-stranded DNA into the cell can contribute to Parkinson's disease.
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Common antidepressant drugs fight cancer in mice, study shows
Monoamine oxidase inhibitors can block the function of a protein, helping T cells to effectively fight cancer, a study in mice has shown.
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Senolytic drugs reduce COVID-19 symptoms in mice, study shows
In pre-clinical studies, senolytic drugs were found to reduce inflammation and death from COVID-19 in older mice.
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Tiny implant cures diabetes in mice without triggering immune response
Scientists have developed an implant that releases insulin-secreting cells which has shown success at treating diabetes in mice.
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Novel DNA vaccine for SARS-CoV-2 effective in rodent models
A new DNA vaccine encoding the SARS-CoV-2 Spike protein has shown promise at protecting mice and hamsters against COVID-19.
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Inhaled nanobodies effective against SARS-CoV-2 in hamsters
Researchers have shown that inhalable nanobodies at ultra-low doses can effectively neutralise SARS-CoV-2 in hamsters.
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Non-opioid based target identified to potentially treat chronic pain
Researchers have discovered that blocking TRPC5 activity treated chronic pain in mouse models of various conditions.
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Analogue of psychedelic ibogaine reverses effects of stress in mice
Tabernanthalog (TBG), similar to the psychedelic drug ibogaine, corrected stress-induced behavioural deficits in mice.
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Researchers synthesise potential anticancer compounds
Scientists have developed six new derivatives of 4-chloro-1,2-dithiol-3-thione, which have all demonstrated anticancer effects in pre-clinical studies.
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Nanoparticle flu vaccine shows promise at protecting mice
Using nanoparticle liposomes, researchers have developed an experimental flu vaccine that has shown success in pre-clinical studies.
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Potential COVID-19 antiviral formulated with siRNA-nanoparticles
Scientists have created an antiviral therapy using lipid nanoparticles that deliver siRNA to the lungs to treat COVID-19 in mice.
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Novel inhibitor blocks myeloma cancer cell growth in mouse model
Having identified the histone demethylase KDM5A as a multiple myeloma target, researchers developed a KDM5 inhibitor to treat the cancer.
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Asthma vaccine shows success in pre-clinical studies
A new conjugate vaccine has shown promise at protecting mice against the effects of cytokines associated with asthma.
