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Drug discovery for COPD treatments
In this article, Drug Target Review’s Ria Kakkad shares some of the most recent progress in discovering a drug for COPD, a disease that remains a major challenge in the medical industry.
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In Vivo
news
Fentanyl vaccine potential ‘game changer’ for opioid epidemic
A study has suggested that a new vaccine could prevent fentanyl from entering the brain, after showing success in rats.
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Experimental cancer vaccine shows promise in animal studies
NIH researchers who intravenously delivered a cancer vaccine to mice report that it increased the number of T cells able to combat tumours.
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Enhanced reprogrammed heart fibroblasts delivered into heart muscle cells
UAB researchers have found that adding TBX20 to the reprogramming cocktail MGT 133 promoted cardiac reprograming.
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Lipid nanoparticle delivery of mRNA could lead to new ‘universal’ COVID-19 treatment
A study has shown that mRNA delivered via lipid nanoparticles blocks multiple variants of SARS-CoV-2 from entering cells in mice.
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NIH awards $3.5 million grant for tuberculosis vaccine research
Texas Biomed and The Access to Advanced Health Institute have been granted $3.5 million to initiate tuberculosis vaccine research, which includes using genetically diverse animal models.
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CEPI awards $5.2m funding for Nipah virus vaccine research
A Boston University researcher has been granted funding for the development pre-clinical models to test potential Nipah virus vaccines.
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Novel Zika vaccine shows promise in animal models
A potential Zika virus vaccine, developed by deleting part of the Zika genome that codes for the viral shell, was effective and safe in mice.
webinar
CHO targeted integration platform for accelerated antibody development
7 September 2022 | By Sartorius
Watch this webinar to hear from Dr Yuansheng Yang as he introduces a CHO cell-based technology allowing simultaneous display and secretion of antibodies for accelerating the process of antibody development.
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Research reveals how maternal antibodies can protect babies from cytomegalovirus
Scientists have found antibodies that summon virus-engulfing white blood cells may play an important role in protecting infants from cytomegalovirus.
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Human urine-derived stem cells have robust regenerative potential
A new study provides the possibility to evaluate the capacity of telomerase-positive human urine-derived stem cells to become a wide variety of other cell types.
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Miniaturising organoid drug screens using nanofibrillar cellulose hydrogels
Drug testing on advanced cell-based models such as organoids has gained in popularity, but significant technical hurdles remain that prevent further assay miniaturisation and higher assay throughput. Through the replacement of animal-derived basement membranes with wood-derived nanofibrillar cellulose hydrogel (NFC), Dr Tijmen Booij and Dr Christian Stirnimann from ETH Zurich,…
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Challenges and opportunities: lessons learned in developing potential gene therapy cures
While the full potential of gene therapies continues to be realised, their successes in rare diseases promote them as a promising treatment modality. Dr Gaurav Shah, Chief Executive Officer of Rocket Pharmaceuticals discusses the future of gene therapies as well as the company’s progress in in vivo and ex vivo programmes.
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Leveraging a dual technology platform to develop gene therapies for a range of rare diseases
In this article, Dr Mary Spellman, Chief Medical Officer and Senior Vice President of R&D at Castle Creek Biosciences, discusses how a versatile dual platform of ex vivo and in vivo gene therapy technologies is being utilised for the development of novel gene therapies for a broad range of rare…
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Drug Target Review Stem Cells ebook
This ebook includes a piece by Daniel Morales- Mantilla, Dr Robin Parihar and Dr Katherine King, from Baylor College of Medicine, on a stem and progenitor cell infusion to improve the survival of mice from sepsis as well as an article by Dr Karen Litwa, East Carolina University, that explores…
