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The growing possibilities for stem cells in pharma
Drug Target Review explores the latest applications of stem cells in modelling disease, drug production and the most recent steps in regenerative medicine provided by research.
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Induced Pluripotent Stem Cells (iPSCs)
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Researchers use iPSCs to treat neuropathic pain in mice
Induced pluripotent stem cells (iPSCs) have been administered to mice with neuropathic pain to provide lasting relief with no side effects.
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MLL gene key to producing hematopoietic stem cells, says research
Researchers investigating childhood leukaemia have discovered that increasing MLL gene expression in iPSCs drives hematopoietic stem cell production, so could be the target of new therapies.
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Accurate model of organ scarring created using stem cells in a lab
Researchers have developed a 'scar in a dish' model derived from human stem cells which mimics the progressive scarring that occurs in human organs and has lead to a drug candidate being identified to stop the progression of fibrosis.
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Machine learning programme used to predict stem cell growth
Researchers have used machine learning to predict the conditions needed for stem cells to develop a certain way, which could be used to grow 3D organ models.
webinar
Phenotypic screening using iPSC-based human disease biology
18 February 2019 | By Tecan and Ncardia
Ncardia, will discuss the application of human iPSC-derived cell-based assays and high throughput screening for drug discovery and development.
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Scientists report using pluripotent stem cells to grow human oesophagal organoids
Scientists have been able to grow human oesophagal tissue entirely from pluripotent stem cells (PSCs), which can form any tissue type in the body...
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3D liver tissue made from stem cells show promising support of liver function
Stem cells transformed into 3D human liver tissue by scientists show promising support of liver function when implanted into mice with a liver disease...
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CRISPRa used to reprogramme skin cells into pluripotent stem cells
Researchers have now for the first time succeeded in converting skin cells into pluripotent stem cells by activating the cell's own genes...
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CRISPR technology may improve accuracy of predicting heart disease risk
Scientists may now be able to predict whether carrying a specific genetic variant increases a person's risk for disease using gene editing and stem cell technologies...
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Expert view: It’s an exciting time for the use of stem cells in research and the treatment of human disease
The Nobel Prize-winning observations and discoveries of John B. Gurdon and Shinya Yamanaka have ignited an explosion of excitement around the potential use of stem cells in research and treatment of human disease.
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Scientists overcome cell rejection in neuron replacement treatment for spinal cord injuries
Scientists have successfully overcome the persistent cell rejection that has hitherto plagued attempts to introduce neural stem cells to replace damaged tissue in pigs.
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Cell therapy aids heart recovery
Biomedical engineers invent an innovative technique to help injured hearts regenerate...
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Early stimulation improves performance of bioengineered human heart cells
Researchers are now able to use induced pluripotent stem cells to form a model of human adult-like cardiac muscle...
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3-D tissue model of developing heart could help drug safety testing
Researchers have combined biomaterials-based cell patterning and stem cell technology to make a 3D tissue model that could mimic early stage human heart development...
