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The future for quality control of mRNA medications
Japanese researchers combine cutting edge mass spectrometry with software analysis to elucidate mRNA structure.
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Scientists investigate the multi-omic landscape of NAFLD-to-NASH progression
Researchers have presented comprehensive multi-omic profiles to identify genes, non-coding RNAs, proteins, and plasma metabolites involved in NAFLD-to-NASH progression.
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Novel method for early disease detection using DNA droplets
Researchers have developed a computational DNA droplet with the ability to recognise specific combinations of chemically synthesised microRNAs that act as biomarkers of tumours.
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Novel prostate cancer resistance mechanism could be a promising target
By inhibiting the activity of microRNA-194 (miR-194), scientists prevented prostate cancer cells from developing treatment resistance in vitro.
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Single interaction could explain the disparity in COVID-19 effects
According to researchers, an interaction between host microRNA and SARS-CoV-2 could be responsible for the range of disease severities.
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Drug target for spinocerebellar ataxia type 1 identified by researchers
A team has found that a mutation in the ATAXIN-1 gene causes spinocerebellar ataxia type 1 (SCA1), presenting a drug target for the condition.
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Coronavirus update: COVID-19 vaccine pre-clinical developments
Drug Target Review rounds up some of the latest news in COVID-19 vaccine candidate R&D.
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Study reveals microRNA as promising hair regrowth drug target
Researchers have revealed that the microRNA miR-218-5p promoted hair growth in mice, so is a promising drug target for hair loss.
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Novel biomaterial could be used to accelerate bone regeneration
In lab conditions, a new biomaterial was able to accelerate bone regeneration by boosting an immune response that encourages repair.
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Novel pathway to target colorectal cancer identified
Researchers have found that PGE2, a signalling molecule involved in inflammation, promotes colorectal cancer progression through a microRNA and targeting that microRNA could have therapeutic potential.
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microRNA could lead to new methods to treat multiple sclerosis
In a pre-clinical model of multiple sclerosis, orally treating susceptible mice with a microRNA from the diseased gut has prevented the disease.
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CNS tumour aggressiveness reduced with new molecule
A microRNA inhibitor has been identified which reduced the sizes of aggressive CNS tumours and improved survival in mice.
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New mechanism of controlling fat production revealed
A new study has shown a new mechanism of controlling fat production in the body which could lead to new therapies to treat obesity.
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New research advances the possibility of regenerating tissue after a heart attack
This research advances the possibility of reviving the heart's regenerative capacities using microRNAs.
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Engineered dl355 virus has the potential to be an effective anticancer treatment
An engineered virus kills cancer cells more effectively than another virus currently used in treatments, according to Hokkaido University researchers...