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Scientists have shown ageing process can be safely and effectively reversed in mice
New research by the Salk Institute has shown cellular rejuvenation therapy safely reverses signs of ageing in mice.
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Molecular pathway shared by two neurodegenerative disorders found
Scientists have gained deeper knowledge about the mislocalisation of a protein, providing a possible therapeutic target that could have implications in treating dementia.
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New research points to a possible driver of Parkinson’s disease
A study has shown how Parkinson’s disease may be driven by cell stress-related biochemical events that disrupt a key cellular clean-up system.
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Possible improvement to Parkinson’s disease treatment shown in study
Research from the University of Copenhagen reveals how Deep Brain Stimulation treatment of walking problems in Parkinson’s disease could be optimised by targeting specific neurons in the brainstem.
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Study may be critical step to understanding cognitive disorders
In a scientific first, researchers have discovered fundamental mechanisms by which the hippocampus region of the brain organises memories into sequences and how this can be used to plan future behaviour.
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Understanding the tau tangles in neurodegeneration could aid treatment discovery
Representing a breakthrough in better understanding how tau proteins cause neurodegenerative disease, scientists have mapped the tau interactome.
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Mechanism that causes ALS nerve destruction unveiled for first time
The study reveals the biological mechanism that causes nerve destruction in amyotrophic lateral sclerosis (ALS), potentially leading to treatments that reverse the disease.
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New target for overeating identified in the brain’s cerebellum
The study uncovered disordered signalling in the brain's cerebellum, offering a novel therapeutic target for Prader Willi syndrome.
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Altered fat metabolism shown to play a key role in ALS
Scientists reveal that higher levels of inflammatory chemicals involved in fat metabolism occur in people with amyotrophic lateral sclerosis.
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Scientists reveal ultrastructure of Huntington’s disease
Researchers used advanced microscopy and proteomics to unveil new findings on Huntington's disease and open avenues to future treatments.
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Intranasal drug may be the future of depression treatments
Groundbreaking study succeeded in the intranasal delivery of an anti-depressant peptide-based drug to the brain in mouse models.
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Scientists explore CA2 neuron mitochondria for memory loss targets
The team will receive $2 million over five years to investigate the CA2 brain region for the development of neurological therapies.
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Soluble fibrinogen a potential target for neurodegeneration
In a pre-clinical study, fibrinogen increased the death of mouse brain neurons, suggeting fibrin can have similar toxic effects on neurons.
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Alterity’s ATH434 improves Parkinson’s-related gastrointestinal dysfunction
ATH434 reversed some of the gastrointestinal damage to the enteric nervous system associated with Parkinson's disease in a pre-clinical study.
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Gene therapy bolsters Parkinson’s drug benefits in pre-clinical study
The gene therapy restored the ability of neurons to convert levodopa to dopamine and may help develop therapies to slow disease progression.
