news
Using organoids to identify drugs for autosomal dominant polycystic kidney disease
Scientists generated kidney organoids and used them to identify potential drugs to treat autosomal dominant polycystic kidney disease.
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Organoids
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Miniaturising organoid drug screens using nanofibrillar cellulose hydrogels
Drug testing on advanced cell-based models such as organoids has gained in popularity, but significant technical hurdles remain that prevent further assay miniaturisation and higher assay throughput. Through the replacement of animal-derived basement membranes with wood-derived nanofibrillar cellulose hydrogel (NFC), Dr Tijmen Booij and Dr Christian Stirnimann from ETH Zurich,…
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Drug Target Review Screening ebook
This ebook features insights into the discovery of a new non-linear chiroptical effect for characterising nanohelices in miniscule volumes, and a novel organoid drug-screening platform with numerous eco benefits.
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Drug Target Review – Issue 2 2022
In this issue are articles focusing on a novel stem cell therapy for hearing loss, how a non-linear chiroptical effect could aid drug discovery and the advantages of cryo-electron tomography for imaging research. Also included are pieces on gene therapy, spheroids and genomics.
news
Researchers use brain organoids to identify neural abnormalities and test gene therapy tools
Scientists used human brain organoids to reveal how a genetic mutation associated with a profound form of autism disrupts neural development, and gene therapy tools to recover the gene’s function effectively rescued neural structure and function.
news
Cilia-free stem cells could open a new way to study rare diseases
A new study has shown that cilia-free human pluripotent stem cells could help scientists understand the causes of polycystic kidney disease and other cilia-linked illnesses.
podcasts
Episode 8 – 3D imaging with Hilary Sherman, Corning Life Sciences & Dr Oksana Sirenko, Molecular Devices
In this episode, experts explore the benefits of 3D imaging and the important considerations for organoid workflows in research and drug development.
news
Nose organoids reveals first stages of SARS-CoV-2 and respiratory syncytial virus infection
Using nose organoids, researchers have highlighted key differences between the infection by SARS-CoV-2 and that of respiratory syncytial virus.
news
Brain organoids may boost drug screening for neurological disorders
Neuroscientists have designed brain organoids to contain both mature neurons and astrocytic glial cells in relative proportions like the human brain.
news
A three-dimensional model for rare neuromuscular disorders
Scientists have created a tiny, bioengineered 3D model that mimics the biology of chronic inflammatory demyelinating polyneuropathy and multifocal motor neuropathy, a pair of rare, devastating neuromuscular diseases.
news
Personalised organoid models for rare spinal cancer
Scientists have successfully created viable organoids from tumour samples from five patients with a rare bone cancer called a chordoma, which has few therapeutic options.
whitepaper
Under the microscope: Unveiling a next-generation imaging system with deep learning technology
The ImageXpress Confocal HT.ai High-Content Imaging System combines premium hardware technology with a self-learning software analysis workflow for increased signal and ultra-fast 3D organoid screening.
whitepaper
Product hub: Scalable and automated 3D cell cultures for high-throughput and high-content screening
Read about hydrogels that provide defined and tuneable material properties that allow the controlled inclusion of biochemical cues.
news
Scientists create brain organoids to understand autism
Researchers have been using brain organoids to understand how a mutated gene affects the brain at its very early stage of development.
news
Researchers create triple-negative breast cancer organoids
Scientists have opened a path towards triple-negative breast cancer treatment, by creating organoids from tumour samples.
