Researchers have shown that topoisomerase TOP2A eliminates negative supercoiling, causing an increase in the number of turns of DNA strands and impacting gene expression.
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A range of imaging and computational techniques were used by researchers to discover the structure of the PH domain of PLEKHA7.
A model of the SARS-CoV-2 Spike protein surface has uncovered vulnerabilities that researchers say could inform the development of COVID-19 vaccines.
Researchers have elucidated the 3D structure of the Taspase 1 enzyme, known to be involved in a range of cancers.
Researchers have imaged the entire Survival Motor Neuron complex using X-ray diffraction analysis, among other techniques.
Insights into the interaction between telaprevir and the SARS-CoV-2 main protease could aid in future COVID-19 drug design, say scientists.
Having revealed the activation mechanism and functional states of A2AR signalling, a GPCR, researchers say this could aid drug discovery.
Researchers are using a new method to isolate the complex between SARS-CoV-2 and the ACE2 receptor to keep it embedded in the cell membrane.
Using X-ray crystallography and simulations, researchers have shown that APT2 is a hybrid between a lipid carrier protein and a hydrolase.
Researchers have produced the first 3D image of the Mediator-bound pre-initiation complex, key in the regulation of gene expression.
Researchers have used computer simulations to model how the SARS-CoV-2 fusion peptide interacts with and penetrates the cell membrane.
Researchers have developed a computer modelling programme that can produce genetic circuits for cellular engineering.
The N439K mutation improves the interaction between SARS-CoV-2 Spike protein and the viral receptor ACE2 and eludes antibody-mediated immunity, say investigators.
A single change to the structure of bacterial ribosomes prevents macrolide antibiotics from binding and killing the bacteria, according to a study.