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A structural insight into HIV drug-resistance mechanisms
New Salk Institute, US, research could lead to the development of new HIV therapeutics that overcome resistance to existing drugs.
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Structural Biology
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‘Lava lamp’ vesicles show how cells could self-organise
Looking at how cells can self-organise could help us understand the way cells manage biochemical processes.
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Scientists discover extensive array of protein folds unexplored in nature
A study out of Japan reveals diversity of protein structures and how they fold in nature, uncovering a myriad of protein topologies.
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New insights on the structural biology of medical cannabis
French researchers underwent a structural study showing that THC cannabinoids inhibit a human enzyme called autotaxin.
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Snapshots of a mouse brain show OPCs nibbling on neurons
A US researcher studied 3D structures of brain cells and connections, revealing new role for oligodendrocyte precursor cells (OPCs), in mice.
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Mapped protein structure of Hepatitis C could lead to vaccine
Scripps scientists have mapped the protein structure of the Hepatitis C virus, paving the way for an effective vaccine.
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Ground-breaking 3D bioprinted tumours aid immunotherapy research
A team of scientists have 3D bioprinted breast cancer tumours and treated them in a new study, offering greater understanding of the disease.
podcasts
Episode 13 – Multiplexing with Dr Luke Gammon, Queen Mary University & Dr David Pointu, Leica Microsystems
Join our experts as they discuss the advantages of multiplexed imaging for a wide range of research and how this technique will develop in the future.
article
A multi-step analysis including GCI reveals novel insight into LPS translocation
Antibiotic resistance is one of the key health challenges of the future. In a new study, researchers have carried out a multi-step analysis to deliver insights into translocation of the hydrophobic and hydrophilic portions of the large lipopolysaccharide molecules through the outer membrane of Neisseria gonorrhoeae. This article summarises their…
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Scientists unveil first molecular-level analysis of Omicron spike protein
Using cryo-electron microscopy, researchers have completed the world’s first molecular analysis of the SARS-CoV-2 Omicron spike protein.
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Researchers engineer protein assembly via artificial protein needles
Japanese researchers have formed ordered biological structures using protein needles, enabling protein self-assembly into lattice structures.
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Bristol Myers Squibb research reveals atomic structure of protein receptor CD47
New Bristol Myers Squibb research has revealed details about the structure of the protein receptor CD47, which helps protect cells from the human immune system.
article
Determining the structure of nanobodies using nuclear magnetic resonance spectroscopy
Scientists at the New York University (NYU) Abu Dhabi have used nuclear magnetic resonance (NMR) techniques to determine the structure of a specific nanobody, Nb23. Drug Target Review’s Victoria Rees spoke with lead researcher Professor Gennaro Esposito to find out how their findings could lead to a better understanding of…
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Researchers simulate hepatitis B infection using computational method
The new study modelled the process of capsid disassembly of the hepatitis B virus at an atomic level to help develop targeted therapies.
news
Novel model developed to resemble aberrant IPF lung epithelium
A new model that closely resembles aged lung epithelium in idiopathic pulmonary fibrosis has been developed, possibly leading to treatments.