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Mitochondria-boosting compound promotes immunotherapy in mice
Researchers have discovered that a small molecule can help some T cells combat tumours during PD-1 blockade immunotherapy in mice.
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Rebalancing the immune system to treat autoimmune disease
Dr Nicolas Poirier reveals how immunotherapies can be designed to recalibrate the immune system for long-term maintenance of autoimmune remission.
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New T-cell discovery could lead to treatments for both bacterial infections and autoimmune conditions
A novel highly activated form of T cells could be suppressed to treat autoimmune conditions and activated in treating bacterial infections.
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Researchers generate atlas of thymus to understand T-cell development
A new study has created an atlas of human thymus development, to reveal which genes are needed for the production of specific T cells.
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Using blue light to control CAR T cells and destroy tumours
Researchers have created a method to activate CAR T cells with blue LED light to successfully combat solid tumours in mice.
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CD229 CAR T-cell therapy treated tumours had lasting response mice
Researchers have created a CAR T-cell therapy which targets the CD229 molecule expressed on all multiple myeloma cells and killed human tumour cells in mice.
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Blocking IL-17 could provide new multiple sclerosis treatment strategy
Researchers have revealed that inhibiting IL-17 could prevent the effects of autoimmune diseases, including multiple sclerosis.
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Precise features of CAR T cell-resistant cancer have been identified
The mechanism that prevents destruction of cancer cells by CAR T-cell therapy has been identified by researchers in Pennsylvania.
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Study identifies gene responsible for T follicular helper cell development
A loss-of-function mutation in the Prkd2 gene has been revealed as a driver of T follicular helper cell development which could be useful for vaccine design.
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Immune cell autophagy discovery could optimise cancer therapies
Researchers reveal importance of IL-15 in T cell autophagy in the liver, presenting a potential strategy to enhance immunotherapies.
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New T-cell therapy could provide universal cancer treatment
Researchers have discovered a new type of T-cell receptor that can kill most cancer types while leaving healthy cells unharmed.
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Process that immune cells use to detect infections and cancers discovered
Researchers have discovered how gamma-delta T cells become activated which could lead to the development of new and improved immunotherapy treatments.
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Immune cells grown in dish from pluripotent stem cells
In a world first, researchers have grown immune cells from pluripotent stem cells in a dish, which could be used to develop immunotherapies or to test autoimmune disease treatments.
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Blimp-1 identified as driver of T-cell activity against cancer
A study has shown that T cells are driven to attack tumours by IL-2 and Blimp-1 in mice, which researchers say could form the basis of cancer therapies.
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Bile acids acting as inflammation regulators may protect against IBD
Research has found that bile acids, converted by gut microbes, act as inflammatory regulators in IBD by modulating the differentiation of T cells in the gut.
