Article: Tips for successful editing in T cells

Posted: 10 September 2020 | | No comments yet

Horizon article on the recipe for success for CRISPR editing in T cells.

Gene editing by CRISPR has led to significant advances in immunotherapy development. CRISPR can be used to rapidly knock out cell surface receptors, thereby limiting concerns of rejection by the immune system if the T cells engineered were not collected from the recipient. CRISPR also offers the ability to knock-in specific sequences into any gene, including chimeric antigen receptors (CARs) which target activated T cells to a specific tumor recognition site.