Case study: Parkinson’s disease modelling for drug discovery

Posted: 11 May 2021 | | No comments yet

The development of a Parkinson’s disease model, using hiPSC-derived neural cells, to assess alpha-synuclein pre-formed fibril-induced toxicity.

Misfolding and aggregation of alpha-synuclein proteins is believed to drive neurodegeneration, and plays a key role in the pathogenesis of Parkinson’s disease. Ncardia created a disease model from a co-culture of hiPSC-derived neurons and astrocytes, that recapitulate these typical pathological features, to enable investigation of the disease pathogenesis and to provide specific and valuable readouts for drug discovery for Parkinson’s disease.

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