article

Current state of NAFLD treatments and the promise of in vitro platforms towards better screening of drug candidates

The heterogeneous pathogenesis of metabolic fatty liver diseases presents researchers with numerous challenges when trying to develop a treatment. This article explores the spectrum of these diseases and presents a novel in vitro platform for screening drug candidates.

diseased liver

Non-alcoholic fatty liver disease (NAFLD), a growing epidemic leading to accumulation of triglycerides (TGs) and free fatty acids (FFAs) in the liver, comprises the early NAFL to its progressive form of non-alcoholic steatohepatitis (NASH).1,2 NAFLD prevalence, which has doubled over the last 20 years, now stands at 20-30 percent in Western countries; and the overall global prevalence is 20-25 percent, making NAFLD the leading cause of chronic liver diease.3-6 Currently, there are no US Food and Drug Administration (FDA)-approved drugs for NAFLD on the market.6 This is mostly due to the enormously complicated nature of NAFLD, highlighted by its recent label as a “multiple hit and organ” disease. The progression of the condition, its complexity and spatial and temporal heterogeneity need to be well understood in order to develop effective therapies.











To read this article in full, please complete the form below. By clicking submit you confirm that you accept our terms and conditions and privacy policy.


*

*

*

*

*

*

*

*

This content is provided to you for free thanks to the kind support of our sponsors: Ncardia, Merck, Horizon Discovery, FortéBio

Send this to a friend