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Formation of nano- and micro-scale drug delivery systems using microfluidic technology

17 October 2014 | By , ,

The recent developments in microfluidic technology have provided an effective microreactor platform for the production of a range of pharmaceutically related materials in both nano- and micro-scale. This can be attributed to the unique characteristics that microfluidic-based reactors offer in terms of controllability and uniformity of the material characteristics, compared…

Synthetic macrocyclic receptors as tools in drug delivery and drug discovery

10 October 2014 | By ,

Macrocyclic compounds (see Figure 1) have fascinated medicinal chemists for generations. The first ones which have been characterised are the naturally occurring cyclodextrins (CDs), cyclic oligomers of glucose, which can be obtained by bacterial synthesis from starch. Calixarenes (CXs) were among the first man-made macrocycles, followed by crown ethers (Pedersen,…

Antibody Discovery Technologies: the partnership between academia and biopharma in the therapeutic monoclonal antibody success story

3 October 2014 | By , ,

The use of monoclonal antibodies and antibody-based molecules as therapeutics to treat patients suffering with severe disease has become a major success story. Due to the exquisite specificity with which they interact with their antigen and the fact that their large binding surface can intervene at sites and targets not…

Drug Target Review – Issue #1 2014

9 May 2014 | By Guido Rasi, Professor Sir Mark Pepys, Kenji Schorpp et al.

We are delighted to welcome you to the inaugural issue of European Drug Target Review, a magazine focused on the changing landscape of the drug discovery industry...

Genomics In-Depth Focus 2014

7 May 2014 | By Kevin V. Morris, Bhupinder Bhullar

In this Genomics In-Depth Focus: Kevin V. Morris discusses the therapeutic potential of RNA directed epigenetic regulation of transcription, and Bhupinder Bhullar looks at drug resistance mechanisms and target selection in disease treatment strategies...

Screening In-Depth Focus 2014

7 May 2014 | By Kenji Schorpp, Christophe Antczak, Balajee Somalinga, Hakim Djaballah

In this Screening In-Depth Focus: Kenji Schorpp looks at targeting the ubiquitin-proteasome system, and experts from Memorial Sloan-Kettering Cancer Center discuss a high content assay opportunity to measure cellular stress response using heat shock proteins...