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Targeting CD36 with antibody inhibits Treg tumour protection in mice
Researchers have discovered that an antibody which targets the CD36 protein prevents Tregs from protecting tumours against immunotherapies in mouse models.
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Cancer
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The fate of cancer is all down to particular proteins
Scientists in Japan have identified an important protein that can impact the course of cancer and its fate in the human body.
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APOBEC3B genetic mutation signatures could be used to target cancers
An innovative new vaccine technique, which sensitises the immune system to the genetic signature of APOBEC mutations (often found in cancers), increases the efficacy of immunotherapies.
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Molecular ‘switch’ could help treat or reverse age-related diseases
A molecular 'switch' that controls the immune machinery responsible for chronic inflammation has been identified which could help treat or even reverse the development of age-related conditions like Alzheimer's, Parkinson's, cancer and diabetes.
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Nanoparticles could be an alternative to antibody immunotherapies
A study has shown that inexpensive nanoparticles can effectively inhibit PD-L1 in cancer cells in the lab and work as well as antibodies, providing a potential alternative immunotherapy.
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Study shows that lung tumour growth can be reduced by inhibiting p38
A new study has shown that the function of the p38 protein is related to the stimulation of cancer cell division and thus enhances tumour growth.
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Research into CDK8 oncogene could improve design of future therapeutics
A study has shown that type II kinase inhibitors targeting CDK8 alone are ineffective because mutations leave them inactive, suggesting future therapies should target CDK8 in complex.
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Novel palladium compound shows potent action against treatment resistant cancer cells
Research demonstrated a complex of palladium and thiosemicarbazone is a more selective and powerful chemotherapeutic than the current standard of care cisplatin.
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Cannabinoid screening reveals anti-tumour properties of CBC and CBG
A high-throughput screening test of different cannabinoids has demonstrated that CBC and CBG exhibit anti-tumour effects.
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DNA-PK identified as potential targeted therapy for cancer
A study has shown that the sensor of a DNA sensing pathway, DNA-PK, could act as an antiviral against tumours.
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Cancer metastasis can be prevented by stopping lipid storage in mice
A study has demonstrated the aggressiveness of cancers is promoted by their ability to store fatty acids in lipid droplets; this discovery could lead to new anti-metastasis therapies.
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Antiviral treatments lead to development of a new kind of cancer drug
Drugs that were being developed to treat enterovirus have also been found to treat certain cancers in mice.
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New drug prevents liver damage, obesity and glucose intolerance in mice
Mice given a novel drug that targets a key gene involved in lipid and glucose metabolism were able to tolerate a high-fat diet regimen without developing significant liver damage.
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Immune cell autophagy discovery could optimise cancer therapies
Researchers reveal importance of IL-15 in T cell autophagy in the liver, presenting a potential strategy to enhance immunotherapies.
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Faster drug discovery could hit ‘undruggable’ targets
A new technique has been developed which has the potential to harness bacteria to produce billions of different drug candidates to treat diseases like cancer.
