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Hit To Lead In-Depth Focus 2017
In this In-Depth Focus we look at a pragmatic approach to hit validation following biochemical high-throughput screening as well as identification of hits and leads for human African trypanosomiasis.
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Drug Target Review – Issue #4 2017
Issue 4 of Drug Target Review looks at artificial intelligence in drug discovery and features In-Depth Focuses on Screening, Hit to Lead and Informatics.
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CXCL5 protein found to stimulate tumour growth in prostate cancer
Researchers identify a pathway that causes tumour acceleration in metastatic prostate cancer cells...
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RT-QuIC testing detects prion protein in the skin of CJD patients
Scientists have detected abnormal prion protein in the skin of patients that have died from Creutzfeldt-Jakob disease...
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Tumour environment found to trigger cells to metastasize
The environment surrounding a tumour can trigger metastatic behaviour in cancer cells...
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Alzheimer’s Tau protein forms toxic complexes with cell membranes
Researchers identify the sequence and structural factors that drive Tau interaction with membranes...
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Pre-diabetes discovery marks step towards precision medicine
Researchers have identified three specific molecules that accurately indicate insulin resistance - a major predictor of diabetes...
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Engineering the gut microbiome may help treat Crohn’s disease
Researchers have singled out a bacterial enzyme behind an imbalance in the gut microbiome linked to Crohn's disease...
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ARBs may solve the global antibiotic crisis by 2020
A British biopharmaceuticals company, have developed Antibiotic Resistance Breakers which can restore the original potency against both Gram-positive and Gram-negative bacteria...
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pIC found to prevent the development of liver cancer
A synthetic double-stranded RNA has potential for use as an anti-liver cancer vaccine...
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Next-generation optogenetic molecules control single neurons
Focused laser beam could help scientists map connections among neurons that underlie behaviour...
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Exclusive speaker interview with Professor Nagy Habib – MiNA Therapeutics/Imperial College London
SMi are delighted to have, Nagy Habib, Head of HPB Surgery, Imperial College London and Co-Founder, MiNA Therapeutics, as the Keynote Address for day 1 at RNA Therapeutics 2018!
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Ancient antiviral response could help treat cancer
By stimulating a patient’s immune system, a drug already in use to treat a blood disorder can prevent the growth of a variety of solid tumours...
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Scientists identify new treatment for Activated PI3-kinase Delta Syndrome
Scientists have identified a new treatment approach for patients with a rare inherited immune disorder...
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Selective PDE4D inhibitor shows potential to treat Fragile X syndrome
Preclinical research suggests the potential utility of BPN14770, as a prospective treatment for Alzheimer's disease...
