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Artificial enzyme catalytic capabilities improved, say researchers
A study has shown that using a particular three-stranded structure can extend the catalytic performance of artificial metalloenzymes.
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Biopharmaceuticals
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Rebalancing the immune system to treat autoimmune disease
Dr Nicolas Poirier reveals how immunotherapies can be designed to recalibrate the immune system for long-term maintenance of autoimmune remission.
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Why invest in creating a modifiable drug framework?
Drug Target Review spoke with CUE Biopharma’s President and CSO to find out how and why they created the ImmunoSTAT platform and the ways it may benefit drug design in the future.
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Smart bioprocessing with the new Eppendorf control system
Flexible and intuitive operation of a wide range of biological processes with the SciVario® twin bioreactor control system.
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Lettuce used to create pulmonary arterial hypertension protein treatment
Researchers have developed a way to produce proteins from lettuce which can effectively combat pulmonary arterial hypertension in animals.
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The growing possibilities for stem cells in pharma
Drug Target Review explores the latest applications of stem cells in modelling disease, drug production and the most recent steps in regenerative medicine provided by research.
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Could Frizzled receptors be the target of new cancer therapeutics?
The G-protein coupled receptor Frizzled, implicated in diseases like cancer, can be targeted with small molecules which could provide the basis for anti-cancer therapeutics, according to researchers.
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Dengue vaccines may be improved by simulating amino acid starvation
Scientists have discovered that a plant-based compound called halofuginone activates a pathway that results in better antibodies and could improve the effectiveness of vaccines.
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Potential antibiotic alternative discovered within bacteria
A study has revealed an enzyme in bacteria that produces a molecule which is toxic to other bacteria and shows promise as an antibiotic substitute.
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A biosynthetic pathway to identify new drug candidates
A new process for identifying and biosynthesising drug candidates has been discovered by researchers at the Carl R Woese Institute for Genomic Biology.
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Researchers reveal how fungi produce potential therapeutic compounds
A team has discovered that fungi use the Diels-Alder reaction to assemble new compounds that have potential pharmaceutical uses.
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Evaluation of therapeutic antibody discovery technologies
Protein therapeutics are a major class of biopharmaceuticals and monoclonal antibodies (mAbs) rule this domain. In this article, Dr Nancy Lopez-Anton outlines the key technologies employed in this important therapeutic discovery area; how they have evolved and what obstacles must be navigated to ensure future success.
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Integrating drug discovery R&D
Pharmaceutical companies are under increasing pressure to get novel drugs to market as quickly as possible. Here, Sheraz Gul discusses how integrating processes could help streamline drug discovery in the future.
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Expert view: Clarification of cell cultures without centrifugation
Monoclonal antibodies are used in a wide range of applications, such as basic research, biopharmaceutical development and in vitro diagnostics.
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Upstream Bioprocessing In-Depth Focus 2019
This In-Depth Focus features articles highlighting the importance of effective data management strategies as well as the recent trends in upstream bioprocessing.
