news
Pharmacological chaperone therapy shown to prevent Alzheimer’s in mice
A new study is the first to describe a novel pharmacological chaperone that is capable of preventing Alzheimer's disease in mice.
List view / Grid view
Disease Research
news
Combination therapy of α -KLOTHO and TGFβR2 improves osteoarthritis
A study has shown that a combination of α-KLOTHO and TGF β receptor 2 (TGFβR2) recovers cartilage in rats with osteoarthritis and could be a new therapy for humans.
news
Researchers use CRISPR to identify proteins that prevent inflammation
New findings using CRISPR have shown that the IL-4 and IL-13 proteins can protect the body against inflammation from autoimmune diseases.
news
Cell division recreated in a test tube demonstrates TPX2 protein role in cancer
Studies have identified that the TPX2 protein recruits the molecular machinery required for the branching microtubule nucleation process, so could be a target for cancer therapies.
news
Levels of neurogenesis could be a therapeutic target in neurodegenerative disease
Research has identified that regions of the brain can regenerate via neural stem cells and the process of neurogenesis which could provide a new avenue for regenerative therapeutics.
news
PCSK6 enzyme plays a key role in vascular disease, according to research
A new study has demonstrated that the enzyme proprotein convert subtilisin/kexin 6 causes structural and functional remodelling in vascular disease, so could be a new therapeutic target.
news
Mutations in non-coding regions of the cancer genome could drive tumour growth
Research into the role of non-coding DNA in cancer development and progression has identified 30 regions that may contribute to tumour growth, which could be therapeutic targets.
article
Could novel sex-linked targets provide an autoimmunity therapy?
Recent research into why autoimmune disorders affect women four times more frequently than men has revealed several novel therapeutic targets that may lead to the development of future treatments.
news
New capillary model could provide new therapies for malaria
Researchers have produced a capillary model which allows investigation of the dynamics of blood flow obstruction in real scale and could be used to test new therapies for P. falciparum malaria.
news
Researchers discover α-synuclein clue to treating Parkinson’s
A study has shown that fruit fly larvae lacking a certain region of the α-synuclein protein did not exhibit Parkinson’s symptoms, indicating a potential target.
news
MLL gene key to producing hematopoietic stem cells, says research
Researchers investigating childhood leukaemia have discovered that increasing MLL gene expression in iPSCs drives hematopoietic stem cell production, so could be the target of new therapies.
news
Researchers find VISTA molecule silences immune system against cancer
A new study shows that the VISTA molecule stops the immune system responding to self-antigens, including those presented by cancer cells, so an anti-VISTA antibody could be a possible therapy.
news
DIRC3 tumour suppressor could be a new target for melanoma therapies
A study has shown that long non-coding RNA called DIRC3 can block melanoma growth and could be used to identify new targets for skin cancer therapies.
news
Novel small molecule could treat Alzheimer’s disease and Dravet syndrome
A new experimental drug was shown by researchers to restore natural brain rhythms in mouse models of Alzheimer’s and promote learning and memory.
news
Genes associated with heavy alcohol use may also impact compulsive behaviour and addiction
A study suggests there may be common genetic pathways between alcohol use disorder and other addictions, so GWAS identification of affected genes could provide the targets for new therapies.
